Tumor-associated neutrophils: friend or foe?

By Z. Fridlender, S. Albelda. Carcinogenesis, 2012

708 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/27047d6f0a862258b5f25ac7097b51d433e2f8ae

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Citations in the corpus

Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis. (2013, neutral): “While antitumor effects have been demonstrated, neutrophils also appear to support the development of metastatic disease under certain conditions (27, 28, 30, 31).”
The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses (2020, background): “Neutrophilia is stimulated by cytokines such as IL-1β, IL-6, G-CSF, and VEGF secreted by stroma cells and tumors (104).”
International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors (2014, neutral): “, 2010) and may promote (1) recruitment to tumors of neutrophils, which are protumorigenic in some tumor systems but antitumorigenic in others (Fridlender and Albelda, 2012); (2) tumor cell proliferation, survival, and chemoresistance (Dhawan and Richmond, 2002); (3) osteoclastogenesis (Pathi et al.”
Phenotypic diversity and plasticity in circulating neutrophil subpopulations in cancer. (2015, background): “Because several studies have suggested a protumor role for neutrophils (De Larco et al., 2004; Fridlender and Albelda, 2012; Kowanetz et al., 2010; Nozawa et al., 2006; Pekarek et al., 1995; Piccard et al., 2012), we hypothesized that LDNs may represent the protumor neutrophil subset.”
Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives (2021, background): “Moreover, C-X-C chemokine receptor 2 (CXCR2), a cytokine receptor that is expressed by CAFs, was proven to be a primary factor participating in the recruitment of neutrophils in tumors, indicating that CAFs might enhance the migration of TANs in a CXCR2-dependent manner [152, 153].”
Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types? (2018, background): “They can directly kill tumor cells and control cancer (Yan et al., 2014), but they can also acquire a pro-tumor phenotype and favor cancer (Fridlender and Albelda, 2012).”
Diverse novel functions of neutrophils in immunity, inflammation, and beyond (2013, background): “The readers are referred to recent reviews for further information on this very interesting but diverse field of study (Gregory and Houghton, 2011; Fridlender and Albelda, 2012).”