Eicosanoids and cancer

By Dingzhi Wang, R. Dubois. Nature Reviews. Cancer, 2010

1,795 citations recorded by the source corpus.

Eicosanoids, including prostaglandins and leukotrienes, are biologically active lipids that have been implicated in various pathological processes, such as inflammation and cancer. This Review highlights our understanding of the intricate roles of eicosanoids in epithelial-derived tumours and their microenvironment. The knowledge of how these lipids orchestrate the complex interactions between transformed epithelial cells and the surrounding stromal cells is crucial for understanding tumour evolution, progression and metastasis. Understanding the molecular mechanisms underlying the role of prostaglandins and other eicosanoids in cancer progression will help to develop more effective cancer chemopreventive and/or therapeutic agents.

Subfields: Biochemistry, Pharmacology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/cf66b9b6bdd6d3651b57644d934d705c605b3bc9

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In Biochemistry

1. Nikos Koundouros
2. G. Poulogiannis
3. R. Ross
4. G. FitzGerald
5. A. Schulze
6. C. Stanton

In Pharmacology

1. Nikos Koundouros
2. G. FitzGerald
3. G. Poulogiannis

In Psychiatry and Mental health

1. Nikos Koundouros
2. C. Mantzoros
3. G. Poulogiannis

Citations in the corpus

• The interaction between ferroptosis and lipid metabolism in cancer (2020, background): “More importantly, ferroptosis is driven by lipid peroxidation,(4) and LPO are also involved in cell signaling events as intermediates for the synthesis of eicosanoids,(8) which regulate cell proliferation, survival, invasion, and migration.(9) In addition, the arachidonoyl (AA) and adrenoyl (AdA) ph”
• Natural forms of vitamin E: metabolism, antioxidant and anti-inflammatory activities and the role in disease prevention and therapy (2014, neutral): “COX- and 5-LOX-catalyzed eicosanoids are known to promote different types of cancer [79].”
• Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy (2022, background): “It’s noticed that LTB4 is one of the most established pro-inflammatory leukotrienes which plays a key role in carcinogenesis.(239) With a Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy Gao et al.”
• Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development (2013, background): “However, the main role of eicosanoids is likely to be the regulation of inflammation, which promotes tumour initiation and progression (Wang and Dubois, 2010).”
• Reprogramming of fatty acid metabolism in cancer (2019, background): “The omega-6 FA arachidonic acid (AA) serves as the main precursor of several eicosanoid species, including prostaglandins, thromboxanes and leukotrienes, each of which has proinflammatory and pro-tumorigenic effects.(72) There are three main mechanisms through which cancer cells can obtain AA: (1) d”
• Health Implications of High Dietary Omega-6 Polyunsaturated Fatty Acids (2012, background): “Eicosanoids are biologically active lipids and include prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs), and hydroxyeicosatetraenoic acids (HETEs) which have all been implicated in various pathological processes such as inflammation and cancer (Table 2) [30].”
• Obesity and cancer risk: Emerging biological mechanisms and perspectives. (2019, background): “Since obesity is related to elevated levels of cyclooxygenase-2 and elevated prostaglandin signaling and synthesis, non-steroidal anti-inflammatory drugs (NSAIDs) may play a role in obesity associated cancers through COX inhibition and decrease of prostaglandin levels [254].”
• Cholesteryl Ester Accumulation Induced by PTEN Loss and PI3K/AKT Activation Underlies Human Prostate Cancer Aggressiveness (2014, background): “Inside cells, AA is released from LDL and converted to a range of eicosanoids that have been implicated in various pathological processes, including inflammation and cancer (Wang and Dubois, 2010).”
• Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity (2015, background): “1260 Cell 162, 1257–1270, September 10, 2015 a2015 The Authors be induced by prostanoids within tumors (Wang and Dubois, 2010).”