Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells.

By F. Trettel, D. Rigamonti, Paige Hilditch-Maguire, V. Wheeler, A. Sharp, F. Persichetti, E. Cattaneo, M. MacDonald. Human Molecular Genetics, 2000

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Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein (2017, methodology): “HTT quantification in fibroblasts and StHdh cells Immortalized StHdhQ111 (Coriell-CH00095, RRID:CVCL_M591) cells (Trettel et al., 2000), immortalized wild type (Coriell-GM02153) and HDQ45 (Coriell-GM03868, RRID:CVCL_1H73) HD fibroblasts ((using SV40 large T antigen) (Lu et al., 2013) and…”
Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor (2015, methodology): “STHdh cells are derived from the conditionally immortalized striatal progenitor cells of embryonic day 14 C57BL/6J mice (Coriell Institute, Camden, NJ, USA) (Trettel et al., 2000).”
Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. (2004, methodology): “Huntingtin Regulates the Dynamics of BDNF-Containing Vesicles We first analyzed the distribution of endogenous wild- BDNF Vesicular Transport Is Specifically Altered in HDtype and polyQ-htt with BDNF in neuronal cell lines derived from knockin mice (Trettel et al., 2000).”
Normal huntingtin function: an alternative approach to Huntington's disease (2005, background): “The evidence in favour of the structural flexibility of the huntingtin backbone is that different protein epitopes are differently accessible to various antibodies depending on their subcellular compartment”