Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor

By R. Laprairie, A. Bagher, M. Kelly, E. Denovan‐Wright. British Journal of Pharmacology, 2015

936 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Molecular Biology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/dad4deae63d80f40358d5a12dd015db19c715fbd

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In Pharmacology

1. U. Kumar
2. Shenglong Zou

Citations in the corpus

• Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System (2018, background): “Despite the fact that CBD has negligible affinity to the CB1R and CB2R, recent studies have suggested that it is an allosteric modulator and an indirect antagonist of CBRs, with the ability to potentiate the effect of THC [177].”