Calcium signaling mechanisms in T lymphocytes.

By R. Lewis. Annual Review of Immunology, 2001

919 citations recorded by the source corpus.

Subfields: Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/f78212bb9df58a3695def097c27c5a387e13e22c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. R. Lewis
2. M. Prakriya
3. S. Feske
4. Jie Zheng
5. M. Trudeau
6. P. Hogan
7. Anjana Rao
8. Sonal Srikanth

In Physiology

1. M. Prakriya
2. R. Lewis
3. Anjana Rao
4. S. Feske
5. P. Hogan
6. Sonal Srikanth
7. Y. Gwack
8. Jie Zheng

Citations in the corpus

• Handbook of ion channels (2015, background): “These patients exhibited a devastating immunodeficiency characterized by impaired T cell activation and effector gene expression [50], which confirmed earlier pharmacological and genetic evidence that CRAC channels orchestrate many aspects of lymphocyte development and function [51,52].”
• STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx. (2005, background): “The resulting sustained Ca2+ signals are required for many physiological responses, such as T cell activation and differentiation [6].”
• ER stress triggers apoptosis by activating BH3-only protein Bim. (2007, methodology): “We therefore treated MCF-7 breast carcinoma-derived cells with thapsigargin (TG), a selective inhibitor of SERCA (seroplasmic endoplasmic reticulum calcium ATPase) (Lewis, 2001) or, as a control, with taxol, a microtubule polymerizing agent that induces apoptosis in MCF-7 cells, and analyzed the lev”
• Molecular Basis of Calcium Signaling in Lymphocytes: STIM and ORAI (2010, background): “When IP3 binds to IP3 receptors (IP3R) in the ER membrane, it effects the release of ER Ca2+ stores, causing the free Ca2+ concentration in the ER to drop below its resting value of ~400–600 μM (9, 11, 13, 14) (Figure 1).”
• Orai1 is an essential pore subunit of the CRAC channel (2006, methodology): “c, d, Ca2þ influx and averaged peak Ca2þ responses in SCID T cells expressing empty vector (2), wild-type Orai1, or Orai1 mutants, after store depletion with thapsigargin and re-addition of 0.”
• Calcium signalling in lymphocyte activation and disease (2007, background): “In lymphocytes, store-operated calcium entry (SOCE) through calcium-release-activated calcium (CRAC) channels is the main mechanism to increase intracellular Ca 2+ concentrations, and it is essential for the activation of and cytokine gene expression by T and B cells (reviewed in Ref”
• The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities (2012, background): “For immune cells, Ca(2) + enters from extracellular spaces but is most often initiated from release of intracellular Ca(2) + stores, predominantly located in the ER (143, 201).”
• CD28-mediated co-stimulation: a quantitative support for TCR signalling (2003, background): “, and that different forms of calcium influx have differential effects on gene expressio”
• STIM1, an essential and conserved component of store-operated Ca2+ channel function (2005, background): “, 2000), gene transcription (Lewis, 2001), and release of cytokines (Winslow et al.”