STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx.
By J. Liou, Man Lyang Kim, W. Heo, Joshua T. Jones, J. Myers, J. Ferrell, T. Meyer. Current Biology, 2005
2,144 citations recorded by the source corpus.
Subfields: Immunology, Molecular Biology, Sensory Systems
View Paper: https://www.semanticscholar.org/paper/95b558e97d9256633f63c7eeba2167ca2e76c8fa
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Citations in the corpus
- Store-Operated Calcium Channels. (2015, positive): “The ability of STIM1 to return to the same sites after multiple rounds of depletion and refilling suggests that ER-PM junctions are stable over minutes, at least at room temperature (199, 354).”
- Handbook of ion channels (2015, methodology): “EF-hand STIM1 mutants with impaired Ca2+ binding form puncta and activate CRAC channels independently of ER Ca2+ store depletion [33,34]; the absence of Ca2+ binding in these mutants essentially tricks the molecules into responding as if stores are depleted.”
- A Micropeptide Encoded by a Putative Long Non-coding RNA Regulates Muscle Performance (2015, neutral): “Intracellular Ca Imaging CytosolicCa levels weremeasured as describedpreviously (Liou et al., 2005), with the exception that retroviral-transduced C2C12 cells or primarymyoblasts were plated on Ibidi m-35mm tissue-culture dishes and cultured for 24 hr in low Ca (0.”
- Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai (2006, background): “More importantly, we conclude that Orai is a bona fide ion channel, based on the following: (1) RNA-interference-mediated knockdown of Orai expression suppresses thapsigargin-dependent Ca2þ influx and CRAC channel activity; (2) overexpression of Orai with or without Stim augments CRAC currents that ”
- Phosphoinositides: tiny lipids with giant impact on cell regulation. (2013, background): “The breakthrough in this field came when largescale small interfering RNA (RNAi) studies identified the STIM1 protein as the ER Ca(2) sensor necessary for SOCE (916, 1296).”
- STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1 (2009, positive): “However, remarkable progress has been made in the past several years after the identification of STIM1 as the ER Ca2+ sensor (Liou et al., 2005; Roos et al., 2005; Zhang et al., 2005) and Orai1 as the pore-forming subunit of the CRAC channel (Prakriya et al., 2006; Vig et al., 2006; Yeromin et al.,…”
- SOAR and the polybasic STIM1 domains gate and regulate the Orai channels (2009, background): “The pairs of prolines (3,5) and (39,40) are required to observe the change in the Orai1 I/V, since the single mutants Orai1(P3A), Orai1(P39A) and Orai1(P40A) behave like wild-type Orai1 when activated by STIM1 (Fig.”
- Molecular Basis of Calcium Signaling in Lymphocytes: STIM and ORAI (2010, background): “EF-hand 1 of STIM1 was recognized from its amino acid sequence (105), and disabling Ca2+ binding by point mutations in EF-hand 1 leads to constitutive localization of STIM1 in puncta (19, 31).”