Calcium signalling in lymphocyte activation and disease

By S. Feske. Nature reviews. Immunology, 2007

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Inositol trisphosphate and calcium signalling mechanisms. (2009, background): “well-established in the lymphocyte activation [63], which is initiated by antigen binding to the T cell receptor (TCR) that then recruits phospholipase Cγ1 (PLCγ1) to produce IP3 (Fig.”
Critical role for calcium mobilization in activation of the NLRP3 inflammasome (2012, background): “Finally, ER Ca2+ release can trigger extracellular Ca2+ influx through store-operated Ca2+ entry (SOCE) (27).”
Molecular Mechanisms of Treg-Mediated T Cell Suppression (2012, background): “Calcineurin, which is activated by Ca 2+ , synergistically contributes to degradation of IκBα when PKCθ is active (Frantz et al., 1994; Feske, 2007).”
Ion Channels in Innate and Adaptive Immunity (2015, background): “Production of Ins(1,3,4,5)P4 mediated by the kinase Itpkb inhibits store-operated calcium channels and regulates B cell selection and activation.”