Shape effects of filaments versus spherical particles in flow and drug delivery.

By Y. Geng, P. Dalhaimer, Shenshen Cai, R. Tsai, M. Tewari, T. Minko, Dennis E. Discher. Nature Nanotechnology, 2007

2,392 citations recorded by the source corpus.

Subfields: Computational Mechanics, Ecology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f753d0c820c1442db1a2af0b2d4bfa00035805df

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Citations in the corpus

The journey of a drug-carrier in the body: an anatomo-physiological perspective. (2012, background): “Similarly, filomicelles with very high aspect ratios (N10) and longitudinal lengths around 10 μm achieve considerably longer circulation times than spherical particles [122].”
Nanoparticle-liver interactions: Cellular uptake and hepatobiliary elimination. (2016, methodology): “Interestingly, worm-like particles with very high aspect ratios seem to exhibit negligible uptake by macrophages and have increased blood circulation [88,150,154].”
Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come (2016, background): “In general, the shape of nanoparticles does have an effect on their cellular uptake and circulation time (Chithrani et al., 2006; Geng et al., 2007; Gratton et al., 2008; Wang et al., 2011).”
Techniques for physicochemical characterization of nanomaterials (2013, background): “In addition to size and surface properties, the shape of nanomaterial can play an important role in drug delivery, degradation, transport, targeting and internalization (Champion et al., 2007; Decuzzi et al., 2009; Euliss et al., 2006; Geng et al., 2007; Gratton et al., 2008; Jiang et al., 2013; Mit”
The effect of particle design on cellular internalization pathways (2008, background): “Several reports have addressed the role of shape and size on cellular internalization (12, 15); however, no particle fabrication techniques currently available have the ability to independently alter one variable at a time, and monitor the effect of each variable.”
Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging (2009, background): “2 Shape—In investigating the effects of NP shape on biodistribution, a limited number of comparative studies have been performed evaluating the biodistribution of non-spherical and rod shaped NPs [65,66,67,68,69,70].”
Using shape effects to target antibody-coated nanoparticles to lung and brain endothelium (2013, background): “Rod-shaped particles may be prepared from various materials, including polymers (19), iron oxide (48), carbon nanotubes (58), DNA/PEG micelles (59), and gold (60) for applications in drug delivery.”