The effect of particle design on cellular internalization pathways

By S. Gratton, P. A. Ropp, P. Pohlhaus, J. Luft, V. Madden, M. Napier, Joseph M. DeSimone. Proceedings of the National Academy of Sciences of the United States of America, 2008

2,778 citations recorded by the source corpus.

Subfields: Cell Biology, Materials Chemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/460d888e484743f933a36da92822b71ebf87ae2c

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Citations in the corpus

Delivering nanomedicine to solid tumors (2010, background): “Also, internalization is faster and more efficient for elongated particles (high aspect ratio), carrying a positive charge”
Better safe than sorry: Understanding the toxicological properties of inorganic nanoparticles manufactured for biomedical applications. (2010, background): “[140] found that rod-shaped nanoparticles enjoyed an appreciable advantage when it comes to cell internalization rates, and suggested that this is reminiscent of the behavior of many rodshaped bacteria.”
The effect of nanoparticle size, shape, and surface chemistry on biological systems. (2012, background): “For instance, a nanoparticle’s shape directly influences uptake into cells: Rods show the highest uptake, followed by spheres, cylinders, and cubes (11).”
NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials. (2009, background): “Although this has been observed in practice using PEGylated polylactide and hydrogel nanoparticles of similar sizes but different charges [156,182], this is not always the rule and it does not preclude the uptake of negatively charged nanoparticles [183].”