Using shape effects to target antibody-coated nanoparticles to lung and brain endothelium

By Poornima Kolhar, A. Anselmo, Vivek Gupta, K. Pant, B. Prabhakarpandian, Erkki Ruoslahti, S. Mitragotri. Proceedings of the National Academy of Sciences of the United States of America, 2013

595 citations recorded by the source corpus.

Subfields: Biomaterials, Biomedical Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/bc55884242c2ac3367525b4cf2fe16982d1e28bf

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Citations in the corpus

Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling (2016, methodology): “Likewise, other microfluidic endothelial devices have been used to assess how changing the geometry and size of drugs and nanoparticles can change the rate that they adhere to and pass through endothelium [38].”
Organ-on-a-Chip Platforms for Studying Drug Delivery Systems (2014, background): “In case of an endothelialized channel, rod-shaped nanoparticles showed high specific targeting and lower non-specific accumulation as compared to sphere-shaped nanoparticles [70].”
Microfluidic Devices for Drug Delivery Systems and Drug Screening (2018, background): “[122] showed that gene silencing efficiency was enhanced in the vascular endothelium by delivering siRNA using needle‐shaped polym ric nanoparticles compared with spherical particles.”