Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging

By Omid Veiseh, J. Gunn, Miqin Zhang. Advanced Drug Delivery Reviews, 2009

1,747 citations recorded by the source corpus.

Magnetic nanoparticles (MNPs) represent a class of non-invasive imaging agents that have been developed for magnetic resonance (MR) imaging. These MNPs have traditionally been used for disease imaging via passive targeting, but recent advances have opened the door to cellular-specific targeting, drug delivery, and multi-modal imaging by these nanoparticles. As more elaborate MNPs are envisioned, adherence to proper design criteria (e.g. size, coating, molecular functionalization) becomes even more essential. This review summarizes the design parameters that affect MNP performance in vivo, including the physicochemical properties and nanoparticle surface modifications, such as MNP coating and targeting ligand functionalizations that can enhance MNP management of biological barriers. A careful review of the chemistries used to modify the surfaces of MNPs is also given, with attention paid to optimizing the activity of bound ligands while maintaining favorable physicochemical properties.

Subfields: Biomaterials, Biomedical Engineering, Electronic, Optical and Magnetic Materials

View Paper: https://www.semanticscholar.org/paper/9619d57e28628e711c7a1d495701c590ba151027

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomaterials

1. Jun Wu
2. N. Bertrand
3. F. Danhier
4. O. Farokhzad
5. N. Kamaly
6. Xiaoyang Xu
7. V. Préat
8. Olivier Féron

In Biomedical Engineering

1. Jun Wu
2. F. Danhier
3. N. Bertrand
4. Xiaoyang Xu
5. N. Kamaly
6. Nariman Farsad
7. V. Préat
8. O. Farokhzad

In Electronic, Optical and Magnetic Materials

1. O. Farokhzad
2. N. Bertrand
3. Sumit Arora
4. S. Jon
5. Wahajuddin

Citations in the corpus

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• A Comprehensive Survey of Recent Advancements in Molecular Communication (2014, background): “neering MC is the medical field [108] with applications in lab-on-a-chip devices [109], cell-on-chips devices [110], pointof-care diagnostic chips [111], and targeted drug delivery [112].”
• Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers (2012, background): “This has been observed, particularly in cases where SPIONs decorated with carboxylic acid groups bind with ligands with multiple amine groups, often leading to inactivation of ligands.(21) Loading of drug molecules along with iron oxide nanoparticles within the coating material represents another ap”
• Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. (2014, background): “NH2 and OH) to increase their reactivity [171-173].”