Wnt signalling in stem cells and cancer

By T. Reya, Hans Clevers. Nature, 2005

3,833 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/8555da5e9b9ac799043ea906e3bdfbe3d472f8c1

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Citations in the corpus

Epidermal homeostasis: a balancing act of stem cells in the skin (2009, background): “Although the post-translational regulatory mechanisms that are involved are likely to be complex, the stabilization of β-catenin enables it to function as a nuclear transcription cofactor for the lymphoid enhancer-binding factor 1 ( LEF1 )/T-cell factor (TCF) family of DNA-binding protein”
Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis. (2009, background): “While it is recognized that the post-pregnancy mammary gland morphologically resembles a virgin gland, permanent alterations in gene expression patterns have been demonstrated (Russo et al. 2005).”
Brain tumour stem cells (2006, background): “Other genes, the expression of which links normal regulation of neural stem cells to aberrant function in brain tumours, include PTEN and elements of the canonical Wnt–β-catenin signalling pathwa”
Epidermal stem cells of the skin. (2006, background): “…and the postnatal hair germ of a Wnt reporter gene driving lacZ under the control of an enhancer composed of multimerized binding sites for the Lef1/Tcf DNA-binding proteins that interact with and are activated by association with β-catenin (DasGupta & Fuchs 1999, Reya & Clevers 2005) (Figure 4b).”
Adipogenesis: from stem cell to adipocyte. (2012, background): “Abbreviations: CDC25B, cell division cycle 25 homolog B; cdk2, cyclin-dependent kinase 2; C/EBP, CCAAT/enhancerbinding protein; CREB, cyclic AMP regulatory element-binding protein; DEX, dexamethasone; DIFF, differentiation; E2F, eukaryotic transcription factor 2; GSK-3β, glycogen synthase kinase-3β;”
Osteoarthritis: pathogenic signaling pathways and therapeutic targets (2023, background): “3): the canonical pathway that is β-catenindependent and the non-canonical pathway that is independent of the β-catenin signaling.(136) β-catenin is a subunit of the cadherin protein complex and the co-activator to promote its downstream target gene transcription.”
EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma. (2008, background): “Wnt-h-catenin signaling plays a pivotal role in embryogenesis and stem cell maintenance ( 39 ) and is known to be activated during liver development (40, 41).”
Bone-marrow haematopoietic-stem-cell niches (2006, background): “Signalling through Notch receptors is involved in many cell-fate decisions and is thought to have a role in the maintenance of stem cells in a variety of tissue”
Two βs or not two βs: regulation of asymmetric division by β-catenin (2007, background): “Because Wnt signals are required for maintenance of some stem cells that are thought to undergo asymmetric cell division for their self-renewal [ 51 ], Wnt signaling might regulate the asymmetric cell division of mammalian stem cells using single b-catenin to regulate their polarities and/ or to act”