Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability.

By G. McGill, M. Horstmann, H. Widlund, Jinyan Du, Gabriela Motyckova, E. Nishimura, Yi-Ling Lin, Sridhar Ramaswamy, W. Avery, H. Ding and 5 more. Cell, 2002

779 citations recorded by the source corpus.

Subfields: Cancer Research, Cell Biology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/f72b18cfb099263957a5cb2399b595c7c963489a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. S. Teitelbaum
2. Scott W. Lowe
3. Hiroshi Takayanagi
4. M. Soengas

In Cell Biology

1. John A D'Orazio
2. Alexandra Amaro-Ortiz
3. Timothy L. Scott
4. Andrea Ballabio
5. Stuart G. Jarrett

In Immunology and Allergy

1. F. Ross

Citations in the corpus

• Melanocyte biology and skin pigmentation (2007, background): “Bcl-2 (B-cell leukaemia/lymphoma 2), a transcriptional target of MIT”
• TFEB at a glance (2016, background): “…cell proliferation and survival by direct upregulation of cell cycle mediators, such as cyclin D2, cyclin D3 and p21 (CDKN1A) (Medendorp et al., 2009; Muller-Hocker et al., 2008), as well as by induction of antiapoptotic genes, including BCL2 and BIRC7 (Dynek et al., 2008; McGill et al., 2002).”
• Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems (2007, background): “MITF, activated by M-CSF, induces BCL-2 (B-cell lymphoma 2), which has a pivotal role in cell surviva”
• Genetic regulation of osteoclast development and function (2003, background): “cgi?l=12043"> Bcl2 is also a MITF target gene, as mi/mi osteoclasts contain greatly diminished levels of the anti-apoptotic molecul”
• UV Radiation and the Skin (2013, background): “UV up-regulates production and epidermal accumulation of melanin pigment in the skin [87–91].”
• Skin melanocytes: biology and development (2013, background): “The MITF activates genes responsible for the migration to the skin, preventing apoptosis in migrating cells, melanin production [70, 76].”
• Apoptosis and melanoma chemoresistance (2003, background): “The dependence of normal melanocytes on Bcl-2 for survival is illustrated by the depigmentation and loss of melanocytes of mice deficient for Bcl-2 or Mitf (Hodgkinson et al., 1993; Yamamura et al., 1996; McGill et al., 2002).”