Skin melanocytes: biology and development
By M. Cichorek, M. Wachulska, Aneta Stasiewicz, A. Tymińska. Advances in Dermatology and Allergology, 2013
600 citations recorded by the source corpus.
In the human skin, melanocytes are present in the epidermis and hair follicles. The basic features of these cells are the ability to melanin production and the origin from neural crest cells. This last element is important because there are other cells able to produce melanin but of different embryonic origin (pigmented epithelium of retina, some neurons, adipocytes). The life cycle of melanocyte consists of several steps including differentiation of melanocyte lineage/s from neural crest, migration and proliferation of melanoblasts, differentiation of melanoblasts into melanocytes, proliferation and maturation of melanocytes at the target places (activity of melanogenic enzymes, melanosome formation and transport to keratinocytes) and eventual cell death (hair melanocytes). Melanocytes of the epidermis and hair are cells sharing some common features but in general they form biologically different populations living in unique niches of the skin.
Subfields: Cell Biology, Dermatology, Immunology
View Paper: https://www.semanticscholar.org/paper/108a4d4d65101280b0112c983a7335079171c34d
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
- Marjan E Askarian-Amiri
- Stacey A. N. D’mello
- G. Finlay
- B. Baguley
Citations in the corpus
- Signaling Pathways in Melanogenesis (2016, background): “Melanoblasts that develop into melanocytes are predominantly found in the basal layer of skin epidermis and hair follicles [9,10], and can be identified by the expression of melanocyte-specific markers such as tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), DOPAchrome tautomerase or tyrosina”
- The single cell transcriptional landscape of mammalian organogenesis (2019, unknown): “For example, cluster 36 (melanocytes) specifically expressed Tyr and Trpm1 26,27 , while cluster 37 (lens) specifically expressed Cryba2.”