A germline-specific class of small RNAs binds mammalian Piwi proteins

By Angélique Girard, Ravi Sachidanandam, Gregory J. Hannon, M. Carmell. Nature, 2006

1,759 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/f71e2a9ff10d141a9a1123ad2cc8777e7634a4d9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. David P. Bartel
2. Gregory J. Hannon
3. John S. Mattick
4. Michael J. Axtell
5. James C. Carrington
6. Alexei Aravin
7. Eugene Berezikov
8. Eric S. Lander

In Plant Science

1. Michael J. Axtell
2. David P. Bartel
3. James C. Carrington
4. Gregory J. Hannon
5. Olivier Voinnet
6. John S. Mattick
7. R. Martienssen
8. Steven E. Jacobsen

Citations in the corpus

• Transposable elements and the epigenetic regulation of the genome (2007, background): “Piwi proteins bind special small RNAs (termed piRNAs) that are larger (26–30 nucleotides) than most small RNA”
• Sorting of small RNAs into Arabidopsis argonaute complexes is directed by the 5' terminal nucleotide. (2008, background): “In several animals, Piwi-interacting RNAs (piRNAs) show a strong preference for a 50 U (Aravin et al., 2006; Girard et al., 2006; Grivna et al., 2006; Lau et al., 2006).”
• PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans. (2008, background): “The latter class of piRNAs is extremely abundant in small-RNA fractionsisolated frompachytene-stage mousespermatocytes: over 80,000 distinct species are derived from large genomic clusters of up to 200 kb (Aravin et al., 2006; Grivna et al., 2006; Girard et al., 2006; Lau et al., 2006).”
• Establishing, maintaining and modifying DNA methylation patterns in plants and animals (2010, background): “melanogaster , mammalian piRNAs were not enriched for repetitive regions of the genom”
• The relationship between non-protein-coding DNA and eukaryotic complexity. (2007, background): “It is also supported by the unfolding discovery of new classes of small regulatory RNAs, including increasing numbers of miRNAs that control a range of developmental processes in plants and animals, via control of mRNA translation and degradation,((114,118,119)) and other RNAs such as snoRNAs that m”
• Applications of next-generation sequencing technologies in functional genomics. (2008, background): “required for germ cell development in mammals and other species [86–88].”
• Distinguishing protein-coding and noncoding genes in the human genome (2007, background): “Interestingly, the platypus piRNA library contained a much larger proportion of repeat-associated species than an equivalent piRNA library from adult mouse testis (Girard et al. 2006) (Fig.”