Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome

By P. Rota, M. Oberste, S. Monroe, W. A. Nix, R. Campagnoli, J. Icenogle, Silvia Peñaranda, B. Bankamp, K. Maher, Min-Hsin Chen and 25 more. Science, 2003

2,527 citations recorded by the source corpus.

Subfields: Animal Science and Zoology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/f6f26a14e4e087a86f0561c1bee460f761d9f391

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Citations in the corpus

The Role of Severe Acute Respiratory Syndrome (SARS)-Coronavirus Accessory Proteins in Virus Pathogenesis (2012, background): “ORF3b is predicted to express the 154 amino-acid 3b protein, also referred to as ORF4 [21], X2 [22] and U154 [57], via an internal ribosomal entry mechanism [21,22,25].”
Coronavirus Diversity, Phylogeny and Interspecies Jumping (2009, methodology): “When SARS-CoV was first identified and its genome sequenced, it was proposed that it constituted a fourth group of coronavirus (48, 49).”
Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2 (2005, background): “The alteration at 479 to a small, uncharged residue is a consistent property of all described SARS-CoV obtained from humans, whereas most civet-derived viruses retain a basic residue at this position (Guan et al, 2003; Marra et al, 2003; Rota et al, 2003; He et al, 2004; Zhang et al, 2004; Song et a”
The Molecular Biology of Coronaviruses (2006, background): “It was thus proposed to be the first recognized member of a fourth group of coronaviruses (Marra et al., 2003; Rota et al., 2003).”
Phylogenetic and recombination analysis of coronavirus HKU1, a novel coronavirus from patients with pneumonia (2005, background): “For SARS-CoV, it was initially proposed that SARS-CoV constituted a distinct group of coronavirus [15, 17].”
Molecular diversity of coronaviruses in bats (2006, background): “…viruses from Himalayan palm civets and a raccoon dog from wild live markets in mainland China have led to a boost in interests in discovery of novel coronaviruses in both humans and animals (Guan et al., 2003; Marra et al., 2003; Peiris et al., 2003; Rota et al., 2003; Woo et al., 2004a, 2004b).”
The spike protein of SARS-CoV — a target for vaccine and therapeutic development (2009, background): “Its genome RNA encodes a non-structural replicase polyprotein and structural proteins, including spike ( S ), envelope ( E ), membrane ( M ) and nucleocapsid ( N ) protein”
Unique and Conserved Features of Genome and Proteome of SARS-coronavirus, an Early Split-off From the Coronavirus Group 2 Lineage (2003, methodology): “These results were interpreted as support for the classification of SARSCoV as the prototype of a novel, fourth group of coronaviruses.(4,5) However, in our opinion, the evidence leading to this conclusion was inconclusive and alternative interpretations, with SARSCoV being an outlier in one of the ”
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus (2003, background): “The S proteins of other coronaviruses, including those of group I and probably SARS-CoV, are not cleaved in virus-producing cells 14, 15, 18 .”
Accessory proteins of SARS-CoV and other coronaviruses (2014, methodology): “Proteins 3a and 3b (p3a and p3b, previously also known as X1 and X2), comprise 274 and 154 amino-acid residues, respectively (Marra et al., 2003; Rota et al., 2003).”
Identification of a new human coronavirus (2004, background): “With a GC content of 34%, HCoV-NL63 has the lowest GC content among the Coronaviridae , which range from 37–42% (ref”