Phylogenetic and recombination analysis of coronavirus HKU1, a novel coronavirus from patients with pneumonia

By Patrick C. Y. Woo, Susanna K. P. Lau, Yi Huang, H. Tsoi, Kwok-Hung Chan, Kwok-Yung Yuen. Archives of Virology, 2005

654 citations recorded by the source corpus.

Summary.Phylogenetic trees constructed using predicted amino acid sequences of putative proteins of coronavirus HKU1 (CoV-HKU1) revealed that CoV-HKU1 formed a distinct branch among group 2 coronaviruses. Of the 14 trees from p65 to nsp10, nine showed that CoV-HKU1 was clustered with murine hepatitis virus. From nsp11, the topologies of the trees changed dramatically. For the eight trees from nsp11 to N, seven showed that the CoV-HKU1 branch was the first branch. The codon usage patterns of CoV-HKU1 differed significantly from those in other group 2 coronaviruses. Split decomposition analysis revealed that recombination events had occurred between CoV-HKU1 and other coronaviruses.

Subfields: Animal Science and Zoology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/fa5ab7bb8d82ae7c970b9dc6a2f10eadf0873623

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Citations in the corpus

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A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2 (2020, background): “The virus has spread worldwide, causing fever, severe 54 respiratory illness and pneumonia(1, 2).”
Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses (2016, background): “HKU1 was also shown to be able to recombine with other animal beta-CoVs, such as MHV, at the nsp3, nsp4, nsp6, nsp7, nps9, and nsp10 genes [77] (Figure 4).”
Molecular diversity of coronaviruses in bats (2006, methodology): “In 2005, we described the discovery, complete genome sequence, clinical features and molecular epidemiology of another novel group 2 human coronavirus, coronavirus HKU1 (CoV-HKU1) (Woo et al., 2005a, 2005b, 2005c, 2005d).”
The deadly coronaviruses: The 2003 SARS pandemic and the 2020 novel coronavirus epidemic in China (2020, neutral): “Since the mid-1960s, seven known human coronaviruses (HCoVs) have been identified [3,4].”
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