Accessory proteins of SARS-CoV and other coronaviruses
By D. Liu, T. S. Fung, K. K. Chong, Aditi Shukla, Rolf Hilgenfeld. 2014
408 citations recorded by the source corpus.
Highlights • The SARS-CoV genome encodes eight accessory proteins; none is essential for RNA replication.• Several appear to be involved in virus–host interactions and to influence the pathogenicity of the virus.• Some of these accessory proteins modulate the interferon pathway and the production of pro-inflammatory cytokines.• Five of the accessory proteins are incorporated into virions as minor structural proteins.• Other coronaviruses including MERS-CoV also encode accessory proteins.
Subfields: Animal Science and Zoology, Immunology, Infectious Diseases
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Citations in the corpus
- Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor (2021, neutral): “Studies of the previous SARS-CoV and MERS-CoV coronaviruses have hinted that these accessory proteins might interact extensively with host proteins to facilitate viral growth and replication [26, 27].”
- Human Coronavirus: Host-Pathogen Interaction. (2019, background): “Several structural proteins (M and N), nonstructural proteins (nsp1 and nsp3), and accessory proteins of SARS-CoV and/or MERS-CoV were identified as interferon antagonists (40, 69, 70).”