Molecular diversity of coronaviruses in bats

By Patrick C. Y. Woo, Susanna K. P. Lau, K. S. Li, R. Poon, Beatrice H. L. Wong, H. Tsoi, Bethanie C K Yip, Yi Huang, Kwok-Hung Chan, Kwok-Yung Yuen. 2006

325 citations recorded by the source corpus.

The existence of coronaviruses in bats is unknown until the recent discovery of bat-SARS-CoV in Chinese horseshoe bats and a novel group 1 coronavirus in other bat species. Among 309 bats of 13 species captured from 20 different locations in rural areas of Hong Kong over a 16-month period, coronaviruses were amplified from anal swabs of 37 (12%) bats by RT-PCR. Phylogenetic analysis of RNA-dependent-RNA-polymerase (pol) and helicase genes revealed six novel coronaviruses from six different bat species, in addition to the two previously described coronaviruses. Among the six novel coronaviruses, four were group 1 coronaviruses (bat-CoV HKU2 from Chinese horseshoe bat, bat-CoV HKU6 from rickett's big-footed bat, bat-CoV HKU7 from greater bent-winged bat and bat-CoV HKU8 from lesser bent-winged bat) and two were group 2 coronaviruses (bat-CoV HKU4 from lesser bamboo bats and bat-CoV HKU5 from Japanese pipistrelles). An astonishing diversity of coronaviruses was observed in bats.

Subfields: Animal Science and Zoology, Infectious Diseases, Modeling and Simulation

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Kwok-Yung Yuen

Citations in the corpus

Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2 (2020, neutral): “Passive administration of these Abs protected mice from lethal challenges with MERS-CoV, SARS-CoV, and closely related viruses, indicating that they represent a promising therapeutic strategy against coronaviruses (Corti et al., 2015; Menachery et al., 2015; Menachery et al., 2016; Rockx et al., 200”
Coronavirus Genomics and Bioinformatics Analysis (2010, background): “The SARS epidemic that originated from southern China in 2003 has boosted interest in all areas of coronavirus research, most notably, coronavirus biodiversity and genomics [5-7].”
Middle East Respiratory Syndrome Coronavirus: Another Zoonotic Betacoronavirus Causing SARS-Like Disease (2015, background): “An intense hunt for animal reservoirs of MERS-CoV was sparked by the early recognition of the close phylogenetic relationship between MERS-CoV and the prototype lineage C CoVs, Ty-BatCoV-HKU4 and Pi-BatCoV-HKU5, which suggested the possibility of MERS-CoV being a zoonotic agent (9, 13, 14, 21, 99).”
Discovery of Seven Novel Mammalian and Avian Coronaviruses in the Genus Deltacoronavirus Supports Bat Coronaviruses as the Gene Source of Alphacoronavirus and Betacoronavirus and Avian Coronaviruses as the Gene Source of Gammacoronavirus and Deltacoronavirus (2012, background): “In these studies, at least nine other novel CoVs were discovered, including two novel subgroups in Betacoronavirus, subgroups C and D (26, 37, 45, 51).”
Recombination, Reservoirs, and the Modular Spike: Mechanisms of Coronavirus Cross-Species Transmission (2009, background): “While the primary human epidemic was quickly controlled and potential host civets were culled as a preventative measure, there is increasing evidence that bat species serve as reservoirs of not only SARS-like coronaviruses but also of multiple strains of coronaviruses, some of which are comparativel”
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A decade after SARS: Strategies to control emerging coronaviruses (2013, background): “Many of these viruses infect various bats and other animal species, and several are phylogenetically similar to known pathogenic human coronaviruses [4] [5] [6] [7] [8] [9] [10] [11] [12] [13] , which suggests that additional emergence events are highly likely to occur.”