Marrow-Derived Stromal Cells Express Genes Encoding a Broad Spectrum of Arteriogenic Cytokines and Promote In Vitro and In Vivo Arteriogenesis Through Paracrine Mechanisms

By T. Kinnaird, E. Stabile, M. Burnett, C. Lee, S. Barr, S. Fuchs, Stephen E. Epstein. Circulation Research, 2004

1,437 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/f6db573b514b63883376e2b1c55fae9c0af72564

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Transplantation of Mesenchymal Stem Cells Improves Cardiac Function in a Rat Model of Dilated Cardiomyopathy (2005, background): “24 Although MSCs have also been shown to produce VEGF, 10,25 there has been no study to compare their production between MSCs and MNCs.”
Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells. (2005, background): “Moreover, recent studies suggest that monocytic cells as well as mesenchymal stem cells augment arteriogenesis via the release of angiogenic growth factors [20–22].”
Vasculotropic, paracrine actions of infused mesenchymal stem cells are important to the recovery from acute kidney injury. (2007, background): “While the predominant belief was that improvement in outcome following organ injury and stem cell administration was the result of replacing damaged cells by differentiated stem cells, we and other groups have shown that paracrine mechanisms are primarily responsible for the organprotective actions ”
Harnessing the Mesenchymal Stem Cell Secretome for the Treatment of Cardiovascular Disease (2012, methodology): “In ischemic animal models, MSCs mediate neovascularization via paracrine signaling (Kinnaird et al., 2004a, 2004b; Matsumoto et al., 2005; Tang et al., 2005) and have antiapoptotic, anti-inflammatory, and antifibrotic effects on cardiomyocytes and endothelial cells (Bartosh et al., 2010; Berry et…”
Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts (2007, background): “Paracrine factors may also enhance angiogenesis, improve the extracellular matrix or modulate the immune/inflammatory respons”
Same or Not the Same? Comparison of Adipose Tissue-Derived Versus Bone Marrow-Derived Mesenchymal Stem and Stromal Cells (2012, positive): “Many studies have also demonstrated that MSC-conditioned media alone could have therapeutic effects, for example, the stimulation of endothelial cell proliferation and migration in vitro and in a hindlimb ischemia model in vivo [78].”
Regenerating the heart (2005, background): “Working with a different cell preparation that has been implicated as containing vascular progenitor cells, Kinnaird et al”