Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice.

By B. Soria, E. Roche, G. Berná, T. León‐Quinto, J. Reig, F. Martín. Diabetes, 2000

911 citations recorded by the source corpus.

Subfields: Surgery

View Paper: https://www.semanticscholar.org/paper/f6bcf7610076ff2a261bf607a8557fe33868d49e

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In Surgery

1. Hans Clevers
2. G. Keller
3. Guoqiang Gu
4. Jolanta Dubauskaite
5. Austin G Smith
6. D. Melton

Citations in the corpus

• Embryonic stem cells: prospects for developmental biology and cell therapy. (2005, background): “This enabled lineage selection and maturation of insulin-expressing cells which, upon transplantation, resulted in the normalization of glycemia in streptozotocin-induced diabetic mice (338).”
• Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. (2002, background): “There is considerable interest in the possibility of growing pancreatic islets for the treatment of diabetes (Bonner-Weir et al., 2000; Ramiya et al., 2000; Soria et al., 2000).”
• Embryo-derived stem cells: of mice and men. (2001, background): “spanning neurodegeneration (Svendsen & Smith 1999), diabetes (Soria et al. 2000), and myocardial infarction (Klug et al.”
• Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitor Cell Transplants Remyelinate and Restore Locomotion after Spinal Cord Injury (2005, methodology): “, 2003) and non-neural (Wiles and Keller, 1991; Klug et al., 1996; Soria et al., 2000) cell types.”
• In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. (2003, background): “The latter can correct the diabetes phenotype in mice (17).”
• Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantation (2005, neutral): “, 2003) and non-neural (Wiles and Keller, 1991; Klug et al., 1996; Soria et al., 2000) cell types.”
• Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis (2013, positive): “…iPSCs can be differentiated towards beta cells in vitro (D’Amour et al , 2006; Zhang et al , 2009; Nostro et al , 2011; Cheng et al , 2012) and in vivo (Soria et al , 2000; Kroon et al , 2008; Sneddon et al , 2012), but the reproducibility of such procedures has been limited (Lysy et al , 2012).”
• Embryonic stem cell differentiation: emergence of a new era in biology and medicine. (2005, methodology): “To enrich for -cells from heterogeneous serum-induced cultures, Soria et al. (2000) developed a selection strategy based on the insulin promoter driving expression of the selectable gene -geo.”
• Multilineage Differentiation from Human Embryonic Stem Cell Lines (2001, methodology): “[ 25-39 ]. From these experiments it is clear that ES cells induced to differentiate in culture follow many of the critical developmental stages found in the normal embryo, and are ultimately able to generate post-mitotic terminally differentiated cell types depending on the particular growth factor”