Multilineage Differentiation from Human Embryonic Stem Cell Lines

By J. Odorico, D. Kaufman, James A. Thomson. Stem Cells, 2001

1,006 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells (2005, background): “They can proliferate indefinitely in vitro (Amit et al., 2000) while maintaining their pluripotent status, and they can also differentiate into a large number of somatic cell types (Odorico et al., 2001).”
Multipotent progenitor cells can be isolated from postnatal murine bone marrow, muscle, and brain. (2002, background): “In contrast, human MAPC, like human ES cells, do not require LIF [43].”
Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. (2005, background): “Embryonic stem cells, hether human or rodent, express high levels of teloerase and thus do not undergo replicative senesence in culture or in vivo (Odorico et al., 2001; Miura t al., 2004).”
Differences between human and mouse embryonic stem cells. (2004, background): “, 1999), which was consistent with observations that human ES cell lines could differentiate into trophoectoderm (Odorico et al., 2001; Thomson et al., 1998a).”
Embryonic stem cell differentiation: emergence of a new era in biology and medicine. (2005, background): “Although not nearly as advanced as the studies with the mouse system, the findings to date indicate that it will be possible to generate a broad spectrum of cell types from them in culture (Schuldiner et al. 2000; Odorico et al. 2001; Pera and Trounson 2004).”