Rab7: a key to lysosome biogenesis.

By C. Bucci, Peter T. Thomsen, P. Nicoziani, J. McCarthy, B. Deurs. Molecular Biology of the Cell, 2000

1,059 citations recorded by the source corpus.

Subfields: Cell Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/f69a4d1149baf9cb6abc2d164ace2ee85cc42c30

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In Cell Biology

1. E. Kominami
2. Ari Helenius
3. T. Ueno
4. Jatta Huotari
5. P. Saftig
6. I. Tanida
7. E. Eskelinen
8. P. Novick

In Physiology

1. P. Saftig
2. E. Eskelinen
3. E. Kominami
4. T. Ueno
5. I. Tanida
6. Ari Helenius
7. Jatta Huotari
8. I. Slaninová

Citations in the corpus

• The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors. (2001, background): “The GDP-bound form mainly localizes to the cytoplasm, whereas the GTP-bound form associates to membranes [8, 9].”
• The lysosome: from waste bag to potential therapeutic target. (2013, background): “The influx of new components is essential, and without incoming endosomal traffic, lysosomes lose their intactness, acidity, and perinuclear localization (Bucci et al., 2000).”
• Role of Rab GTPases in Membrane Traffic and Cell Physiology (2011, background): “Rab7 is a critical regulatory component that directs traffic in the endosomal pathway to the lysosome (44, 66).”
• Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. (2012, neutral): “Activation of the mTORC1 pathway by amino acids correlates with the movement of mTORC1 from an undefined location to a compartment containing Rab7 (Sancak et al., 2008), a marker of late endosomes and lysosomes (Bucci et al., 2000).”
• Effect of NaCl on in vitro plant regeneration from embryogenic callus cultures of 'cv IR 64' indica rice ( Oryza sativa L.) (2011, background): “In animal and yeast cells, Rab7 GTPase is generally thought to be required for the formation of lytic compartments (Bucci et al., 2000; Rosales et al., 2009) and the Rab7 protein was found localized to late endosomes and lysosomes/vacuoles (Bruckert et al.”
• A Rab1 GTPase Is Required for Transport between the Endoplasmic Reticulum and Golgi Apparatus and for Normal Golgi Movement in Plants (2000, background): “The equivalent asparagine-to-isoleucine substitution in many members of the Ras superfamily has provided much useful information about the cellular functions of the respective wild-type GTPases (Schmitt et al., 1988; Bucci et al., 1992, 2000; Tisdale et al., 1992).”
• Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations (2010, neutral): “Other key aspects of lysosomal biogenesis and function were also not detectably altered in PS1 KO cells, such as the delivery of cathepsins and LAMPs to late endosome/lysosomes and the distribution and levels of rab7 required for lysosome maturation (Bucci et al., 2000).”
• Wnt Signaling Requires the Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes (2010, background): “CA-LRP6 signalosomes colocalized with the late endosomal marker Rab7-GFP (Figures 1M–1R) in 62% ± 7% of the GSK3 puncta, indicating that GSK3-RFP relocated to MVBs or lysosomes (Bucci et al., 2000).”
• Endosome maturation (2011, background): “Subsequent studies in mammalian cells demonstrated that expression of dominant negative mutants of Rab7 results in dispersal of endosomes, a block in cargo trafficking to the lysosomes, and the deterioration of lysosome acidification and functionality (Bucci et al, 2000).”
• Role for Rab7 in maturation of late autophagic vacuoles (2004, methodology): “Overexpression of the T22N mutant of Rab7 has been used to inhibit the function of endogenous Rab7 (Bucci et al., 2000).”