Toll-dependent selection of microbial antigens for presentation by dendritic cells

By J. Blander, R. Medzhitov. Nature, 2006

887 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/f653d05fa1efcb40e4aaee24a11453556d457cce

How researchers see this paper

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In Immunology

1. R. Coffman
2. Noah W. Palm
3. Mihai G. Netea
4. R. Medzhitov
5. A. Sher
6. N. Gow
7. Gordon D. Brown
8. R. Seder

Citations in the corpus

• NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation (2010, background): “In addition, continued TLR signaling within phagosomes facilitates increased class II–associated invariant chain peptide exchange in LAMP-1 + MHC class II compartments leading to enhanced MHC class II surface expression concomitant with DC maturatio”
• Dendritic-cell immunotherapy: from ex vivo loading to in vivo targeting (2007, background): “Moreover, an elegant study by Blander and Medzhitov shows that both the antigen and TLR ligand need to co-localize within the same phagosome for efficient MHC class II antigen presentation to occu”
• Recognition of microorganisms and activation of the immune response (2007, background): “For MHC class II molecules, the antigenic peptides selected for presentation derive from the phagosome in which the pathogen was internalized in response to the triggering of TLRs or other PRR”
• Vaccine Adjuvants: Putting Innate Immunity to Work (2010, background): “Several key studies (Blander and Medzhitov, 2006; Joffre et al., 2009; Sporri and Reis e Sousa, 2005) have shown that TLR activation in the same DC presenting the antigen is critical for CD4+ T cell activation and Th1 cell differentiation.”
• Virulence and Immunomodulatory Roles of Bacterial Outer Membrane Vesicles (2010, background): “Recent investigations into how TLR ligand sensing impacts other phagocyte functions such as phagosomal maturation, the selection of antigens for MHC presentation, and dendritic cell maturation indicate that the immune system may be best adapted to sensing a “mixture” of LPS and other OM bacterial co”
• Pattern recognition receptors and control of adaptive immunity (2009, background): “Similarly, co-occurrence of antigens and Toll-like receptor (TLR) ligands in the same phagosome (which normally only happens if the two are physically associated, for example as parts of the same bacterial cell), signals the microbial origin of the antigen and promotes selection of microbial antigen”
• An integrated model of the recognition of Candida albicans by the innate immune system (2008, background): “TLRs do not mediate fungal uptake, but they might be involved in directing the subsequent maturation of the phagosom”
• Bio-inspired, bioengineered and biomimetic drug delivery carriers (2011, background): “Co-delivery of danger signals and antigens to a common phagosomal compartment by antigen-carrying particles has been suggested as a key mechanism by which APCs distinguish harmless environmental antigens from genuine pathogenic threat”
• Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction (2012, background): “NPs may allow co-delivery of antigen and immunostimulatory molecules to the same intracellular compartment in antigenpresenting cells (APCs) (9) and promote cross-presentation of antigens, enhancing CD8þ T-cell expansion and functionality (10–12).”