Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells
By R. Florêncio-Silva, G. R. S. Sasso, E. Sasso-Cerri, M. Simões, P. Cerri. BioMed Research International, 2015
1,809 citations recorded by the source corpus.
Bone tissue is continuously remodeled through the concerted actions of bone cells, which include bone resorption by osteoclasts and bone formation by osteoblasts, whereas osteocytes act as mechanosensors and orchestrators of the bone remodeling process. This process is under the control of local (e.g., growth factors and cytokines) and systemic (e.g., calcitonin and estrogens) factors that all together contribute for bone homeostasis. An imbalance between bone resorption and formation can result in bone diseases including osteoporosis. Recently, it has been recognized that, during bone remodeling, there are an intricate communication among bone cells. For instance, the coupling from bone resorption to bone formation is achieved by interaction between osteoclasts and osteoblasts. Moreover, osteocytes produce factors that influence osteoblast and osteoclast activities, whereas osteocyte apoptosis is followed by osteoclastic bone resorption. The increasing knowledge about the structure and functions of bone cells contributed to a better understanding of bone biology. It has been suggested that there is a complex communication between bone cells and other organs, indicating the dynamic nature of bone tissue. In this review, we discuss the current data about the structure and functions of bone cells and the factors that influence bone remodeling.
Subfields: Molecular Biology, Oncology, Orthopedics and Sports Medicine
View Paper: https://www.semanticscholar.org/paper/e4f87ba9569db894723c98093920e789f18dccd0
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Citations in the corpus
- Polycaprolactone as biomaterial for bone scaffolds: Review of literature. (2020, background): “The inorganic component consists mainly of calcium and phosphate ions which nucleate to form small crystals of hydroxyapatite.(2,3) The interactions between collagen, hydroxyapatite, and various organic and inorganic components of bone lead to its structural organisation and typical mechanical prope”
- Calcium Phosphate Bioceramics: A Review of Their History, Structure, Properties, Coating Technologies and Biomedical Applications (2017, background): “The synthesis of bone matrix by osteoblasts occurs in two main steps: deposition of organic matrix and its subsequent mineralization [123].”