Role of Microglia in Central Nervous System Infections

By R. B. Rock, G. Gekker, Shuxian Hu, W. Sheng, M. Cheeran, J. Lokensgard, P. Peterson. Clinical Microbiology Reviews, 2004

713 citations recorded by the source corpus.

Subfields: Microbiology, Neurology, Virology

View Paper: https://www.semanticscholar.org/paper/a46224f4afa4cfd51ff0bac95da337f17eb24f00

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Neurology

1. M. Block
2. Jau-Shyong Hong
3. S. Woodburn
4. C. Nemeroff
5. J. Bollinger
6. E. Wohleb
7. Eléonore Beurel
8. M. Toups

Citations in the corpus

• Microglia-mediated neurotoxicity: uncovering the molecular mechanisms (2007, background): “, such as CD14, major histocompatibility complex (MHC) molecules, chemokine receptors and several other marker”
• Cytokines and Chemokines at the Crossroads of Neuroinflammation, Neurodegeneration, and Neuropathic Pain (2013, background): “Since the pneumococci can cross the BBB, microglia may respond directly to intact bacteria or to pneumococcal cell wall antigens and produce a wide array of inflammatory mediators including TNF, IL-6, IL-12, keratinocyte-derived chemokine (CXCL1/KC), CCL2/MCP-1,CCL3/MIP-1α, CXCL2/MIP-2, andCCL5/RANT”
• The semantics of microglia activation: neuroinflammation, homeostasis, and stress (2021, background): “Meningitis In cases of CNS infection, neuroinflammation caused by microglia activation is critical for detecting and eliminating pathogens, but is not without consequence [77].”
• The Bidirectional Relationship of Depression and Inflammation: Double Trouble (2020, background): “Indeed, many of the bacterial and viral infections we discussed previously associated with depression, induce microglia activation (Rock et al., 2004).”
• Central Nervous System Tuberculosis: Pathogenesis and Clinical Aspects (2008, background): “Another possible mechanism of immune modification that may be involved is that corticosteroids influence the response of microglial cells, which are the resident macrophages in the CNS and are the only cells productively infected in the brain (173).”