Heat-Evoked Activation of the Ion Channel, TRPV4

By A. D. Güler, Hyosang Lee, Tohko Iida, I. Shimizu, M. Tominaga, M. Caterina. Journal of Neuroscience, 2002

1,000 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/f5981acb79cd9df2646e5591db749f6a43602ab5

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In Cellular and Molecular Neuroscience

In Endocrine and Autonomic Systems

Alexei Verkhratsky

In Sensory Systems

Citations in the corpus

The TRP Superfamily of Cation Channels (2005, background): “J. Vriens, H. Watanabe, A. Janssens, G. Droogmans, T. Voets, B. Nilius, Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4.”
Trp ion channels and temperature sensation. (2006, background): “Activation of TRPV4 at room temperature by hypotonic cell swelling is moderate; however, this response is augmented by an increase in temperature to 37◦C (Guler et al. 2002).”
TRP Channels (2012, neutral): “It was reported as a temperature sensor in skin, sensory neurons, and hypothalamus, however, more recent results show that behavioral responses toward thermal stimulation in Trpv4 knockout mice are only changed under inflammatory conditions and not in the normal tissue (134,222,235,236,325,396,411).”
Cellular and Molecular Mechanisms of Pain (2009, neutral): “When heterologously expressed, both TRPV2 and TRPV4 have been shown to respond to changes in osmotic pressure (Guler et al., 2002; Liedtke et al., 2000; Mochizuki et al., 2009; Strotmann et al., 2000).”
Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurons. (2005, background): “Unfortunately, as an inhibitor ruthenium red is rather nonspecific as it also inhibits VGCC (97) epithelial Ca(2) channels ECaC1 (459), TRPV channels (194), GABA release from hippocampal synaptic terminals (568), and mitochondrial calcium uptake (534).”
ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. (2003, background): “TRPV4, originally described as an osmo-sensor, has also beenWC1E 6BN United Kingdom shown to be activated by warm temperatures (Guler et al., 2002; Liedtke et al., 2000; Strotmann et al., 2000).4 Nervous System Research Novartis Pharma AG Much less is known about channels that sense cold.”