miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely

By Beiyan Zhou, Stephanie W. Wang, Christine Mayr, David P. Bartel, H. Lodish. Proceedings of the National Academy of Sciences of the United States of America, 2007

624 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f52ca5eb86ac601be3ec7880bb12a54cf0a4d44e

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Citations in the corpus

The Role of MicroRNAs in Human Diseases (2010, background): “Another study (91) has demonstrated that miR-181 is involved in regulation of haematopoietic lineage differentiation and several miRNAs have been reported to regulate B-cell differentiation, including the miR-17-92 cluster and miR-150 (92 - 94) .”
MicroRNAs: key regulators of stem cells (2009, background): “Within the lymphoid lineage, the differential expression of miR-150 regulates lineage decision between T cells and B cell”
Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells through targeting SOCS1 (2009, methodology): “psiCheck2 luciferase reporter plasmids (Promega) containing either WT or mutated SOCS1 3′ UTR and miR155- or control miR150-expressing pMDH-PGK-EGFP plasmids (Zhou et al., 2007) were co-transfected into HEK293T cells using Fugene 6 transfection reagent (Roche).”
microRNAs and the immune response (2009, background): “Overexpression of miR-150 which is normally increased during the maturation of both T-cell and B-cell has also been shown to block the pro-B-cell to pre-B-cell transition although this had no effect upon the formation of either CD4 and CD8 T-cells or myeloid cells [35].”
MicroRNAs in development and disease. (2011, background): “When prematurely expressed, though, it halts B-lymphocyte maturation at the pro-B cell stage, while its effect on T-cell development was inconsistent (675, 714).”
MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death (2008, background): “Furthermore, miR-150, found to exist at high levels in mature B and T cells but not their progenitors (Zhou et al., 2007), is required for mature B-cell development and the attenuation of the humoral immune response by translational repression of Oncogene c-Myb (Xiao et al., 2007).”
MicroRNAs: new regulators of immune cell development and function (2008, background): “A combination of gain-of-function and loss-of-function mouse models established in several laboratories has defined the physiological function of miR-150 in hematopoietic developmen”
Physiological and pathological roles for microRNAs in the immune system (2010, background): “Constitutive expression of miR-150, which has a dynamic expression profile in the early B cell lineage, causes a block at a proximal stage of B cell development, the pro-B to pre-B cell transitio”
Biological principles of microRNA-mediated regulation: shared themes amid diversity (2008, background): “miR-150 is a well conserved miRNA that is specifically expressed in the haematopoietic system in mature T and B cells, and its misexpression in immature B cells blocks their differentiatio”