Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression

By D. E. Nelson, Adaoha Elizabeth Ihekwaba, M. Elliott, James R. Johnson, C. A. Gibney, B. E. Foreman, G. Nelson, V. Sée, C. Horton, D. Spiller and 9 more. Science, 2004

1,148 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/f524615f85ad6c945ddcf885ba3a05ad3048abc4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. N. Perkins
2. J. Hong
3. M. Park
4. Alexander Hoffmann
5. M. Tuzcu
6. Jan Lankelma
7. Frank J. Bruggeman
8. T. Ohtsuka

In Immunology

1. N. Perkins
2. J. Hong
3. M. Park
4. M. Tuzcu
5. H. Yazlak
6. C. Orhan
7. F. Akdemir
8. G. Natoli

In Pharmacology

1. Jan Lankelma
2. Frank J. Bruggeman
3. Hans V. Westerhoff
4. N. Perkins
5. J. Hornberg

Citations in the corpus

• The effect of lycopene on antioxidant status in rainbow trout (Oncorhynchus mykiss) reared under high stocking density (2014, positive): “This complex then recruits other proteins such as RNA polymerase, which transcribes downstream DNA into mRNA, which, in turn, is translated into protein, which results in a change of cell function (Nelson et al., 2004).”
• Encoding and Decoding Cellular Information through Signaling Dynamics (2013, positive): “As an example of pharmacological perturbation of NF-kB dynamics, treatment of cells with leptomycin B (LMB) blocks nuclear export, thereby trapping the inactive NF-kB-IkBa complex in the nucleus (Nelson et al., 2004) (Figure 4A).”
• Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway (2006, methodology): “Following activation by TNF, RelA can dynamically oscillate between the nucleus and cytoplasm (Nelson et al., 2004).”
• Transcriptional regulation via the NF-κB signaling module (2006, background): “…and RelA-responsive IkBa by transient transfection resulted in oscillatory activity in single cells as revealed by video microscopy in single cells (Nelson et al., 2004), although the resulting increase in the green fluorescence protein-fusion effector molecules can alter the dynamic behavior…”
• Roles of NF-κB in Cancer and Inflammatory Diseases and Their Therapeutic Approaches (2016, background): “Active NF-κB turns on the expression of genes that keeps the cell proliferating and protects the cell from conditions that would otherwise cause it to die via apoptosis [36].”
• Network resilience (2020, background): “[777]; how the specie abundance evolves during a time period [778]; how many individuals are newly affected by or recovered [779] from a certain disease? Modelling such processes require determinations of equation forms and a set of parameters, which are not easy to achieve due to the complexity and”
• The Hes gene family: repressors and oscillators that orchestrate embryogenesis (2007, background): “Furthermore, recent studies have revealed that, other than the circadian clock genes, Hes genes are not the only oscillators (Nelson et al., 2004; Lahav et al., 2004).”
• Minimal model of spiky oscillations in NF-κB signaling (2005, background): “Recent experiments have found oscillations in the nuclearcytoplasmic translocation of the NF-κB transcription factor [Hoffmann et al. (2002) Science 298, 1241; Nelson et al. (2004) Science 306, 704.]”