Roles of NF-κB in Cancer and Inflammatory Diseases and Their Therapeutic Approaches

By M. Park, J. Hong. Cells, 2016

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Nuclear factor-κB (NF-κB) is a transcription factor that plays a crucial role in various biological processes, including immune response, inflammation, cell growth and survival, and development. NF-κB is critical for human health, and aberrant NF-κB activation contributes to development of various autoimmune, inflammatory and malignant disorders including rheumatoid arthritis, atherosclerosis, inflammatory bowel diseases, multiple sclerosis and malignant tumors. Thus, inhibiting NF-κB signaling has potential therapeutic applications in cancer and inflammatory diseases.

Subfields: Cancer Research, Complementary and alternative medicine, Oncology

View Paper: https://www.semanticscholar.org/paper/7531d5b56178f393f7f0cab1155ca0eee9de7e09