Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2- cancer cells are similarly tumorigenic.

By Lubna Patrawala, Tammy Calhoun, Robin Schneider‐Broussard, Jianjun Zhou, K. Claypool, D. Tang. Cancer Research, 2005

992 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/f4f4c68bc8db8977e9ea34c76d63bc0b894b0f41

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Citations in the corpus

Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. (2006, background): “EGFR FISH was performed using centromere 7 and an EGFR probe set ( Vysis ) .”
Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells (2006, methodology): “In contrast, the highly purified ABCG2þ (which mediates the SP phenotype in some cell types) PCa cell population has very similar tumorigenic potentials to the ABCG2 cells (Patrawala et al., 2005).”
Molecular definition of breast tumor heterogeneity. (2007, background): “Subsequent studies in breast and prostate cancer confirmed that CD44+ cells are tumorigenic when injected into immunodeficient mice and have progenitor-like properties (Patrawala et al., 2005; Ponti et al., 2005).”
Identification of Gastric Cancer Stem Cells Using the Cell Surface Marker CD44 (2009, background): “which expressed ABCG2, an ATP-binding cassette half-transporter that is associated with SP cells, had a similar tumorigenicity as ABCG2-negative cells [54].”
let-7 regulates self renewal and tumorigenicity of breast cancer cells. (2007, methodology): “Both the mammospheres and sorted cells, composed mostly of BT-IC and EPC (Al-Hajj et al., 2003; Ponti et al., 2005), from patients in Table S1A, had reduced let-7 as compared with either adherent cells or tumor cells that were not CD44+CD24 (p < 0.01).”
Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors. (2006, background): “It has been shown that stem-like ‘‘side-populations’’ in established brain tumor cell lines are uniquely able to form xenografts (25, 26).”
Genetics and biology of prostate cancer (2018, background): “Several prostate cancer cell-intrinsic chemoresistance mechanisms include activation of ABCG2 (Robey et al. 2001; Imai et al. 2004; Patrawala et al. 2005), activation of PI3K signaling (Lee et al. 2004), loss of RAS-GTPase-activating protein DAB2IP (Wu et al. 2013), up-regulation of cancer stem…”
Cyclopamine‐Mediated Hedgehog Pathway Inhibition Depletes Stem‐Like Cancer Cells in Glioblastoma (2007, background): “lines such as C6, U87-MG, and U373 and that the side population within the C6 and U373 lines appears to be uniquely capable of forming tumor xenografts [31, 49 ].”