NLRs join TLRs as innate sensors of pathogens.

By Fabio Martinon, J. Tschopp. Trends in immunology, 2005

700 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/f48631299cdd709df420be5093403866135cfa3b

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In Immunology

Citations in the corpus

Pathogen recognition and innate immunity. (2006, positive): “Proteins in this family possess LRRs that mediate ligand sensing; a nucleotide binding oligomerization domain (NOD); and a domain for the initiation of signaling, such as CARDs, PYRIN, or baculovirus inhibitor of apoptosis repeat (BIR) domains (Inohara et al., 2005; Martinon and Tschopp, 2005).”
The inflammasomes: guardians of the body. (2009, background): “With this in mind, the complexity and diversity of inflammasomes may reflect the multitude of pathogens and danger signals that are detected in specific locations, whereas the conservation of TLRs and IL-1β/IL-18 receptor signaling cascades emphasizes the importance of MyD88 signaling in innate immu”
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry (2010, background): “The recognition of pathogens by the innate immune system relies on the detection of motifs that are highly conserved among pathogens, called pathogen-associated molecular patterns, by germline-encoded pattern-recognition molecule”
Signalling pathways and molecular interactions of NOD1 and NOD2 (2006, background): “Striking evidence for this comes from the recent discovery that some members of the NACHT (domain present in NAIP, CIITA, HET-E and TP1)-LRR (leucine-rich repeat) family (the NLR family) ? which includes both nucleotide-binding oligomerization domain (NOD) proteins and NACHT-, LRR- and pyrin-domain-”
Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector? (2015, neutral): “NLRP3 inflammasomes instigate the innate immune response in different cells, and its activation is particularly critical for the sterile inflammatory reaction to DAMPs during chronic degenerative diseases (81, 122).”
Activation of innate immune antiviral response by NOD2 (2009, background): “A third class of PRR includes members of the nucleotide-binding domain (NBD)– and leucine-rich-region (LRR)–containing family of cytoplasmic proteins (known as NLRs); these proteins respond to bacterial PAMPs to activate the transcription factor NF-κB and mitogen-activated protein kinase pathway”
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration (2007, background): “The inflammasome complex consists of a NALP protein as well as the adapter protein ASC, which connects the NALP proteins to the third component, namely caspase-1.(3) An exception is NALP1, which can directly bind and activate caspase-1 and/or caspase-5 via its unique C-terminal caspase-associated re”
Dectin-1: a signalling non-TLR pattern-recognition receptor (2006, neutral): “For example, the NLR (NACHT?leucine-rich repeat) famil”
A pilot study of IL-1 inhibition by anakinra in acute gout (2007, background): “Activators of the NALP3 inflammasome include ATP, the microbial cell-wall component muramyl dipeptide and bacterial RNAs [8-10].”