Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states.

By M. Badman, P. Pissios, A. Kennedy, G. Koukos, J. Flier, E. Maratos-Flier. Cell Metabolism, 2007

1,524 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f4679c1f0b61b717bd95e9977eab95696fc025ff

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. Gerald I. Shulman
2. V. Samuel
3. B. Spiegelman
4. D. Clegg
5. B. Palmer
6. David M. Sabatini
7. M. Laplante

In Molecular Biology

1. Gerald I. Shulman
2. V. Samuel
3. S. Kersten
4. B. Spiegelman
5. Jun Wu
6. E. Maratos-Flier
7. D. Moller
8. N. Itoh

Citations in the corpus

• Peroxisome Proliferator-Activated Receptor Alpha Target Genes (2010, background): “Ketogenesis/ketolysis Acat1 [24, 62, 68], Bdh [62], FGF21 [24, 62, 90–92], Hmgcl [62], HMGCS2 [24, 62, 93–95]”
• β-Hydroxybutyrate (2017, neutral): “As described above, mTOR is also a checkpoint in the activation of ketogenesis; inhibition of mTORC1 is required to activate the transcription factors and hormones that control ketogenesis (4, 117).”
• Increased Fibroblast Growth Factor 21 in Obesity and Nonalcoholic Fatty Liver Disease (2010, background): “For CPT1, p < 0.03 NAFLD vs controls and 0.0003 NASH vs controls. p = NS for PPARα and CD36 across all groups Gastroenterology.”
• Non-Alcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases (2017, positive): “FGF21 coordinates the metabolic shift from fed to fasted states; FGF21 regulates hepatic ketogenesis, gluconeogenesis, and adipose lipolysis (Badman et al., 2007; Inagaki et al., 2007).”
• Fibroblast growth factor 21 corrects obesity in mice. (2008, result): “As expected based on previously reported results (2, 4, 5, 7), insulin levels were suppressed, and this effect reached its maximum at the lowest dose of FGF21.”
• Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. (2013, background): “FGF21 has been shown to exert multiple metabolic effects in the liver, including alleviation of diet-induced hepatic insulin resistance and hepatic steatosis (Xu et al., 2009b) and regulating hepatic gluconeogenesis and ketogenesis (Potthoff et al., 2009; Badman et al., 2007).”
• Homeostasis, Inflammation, and Disease Susceptibility (2015, neutral): “FGF21 is produced by hepatocytes during fasting (Badman et al., 2007; Inagaki et al., 2007) and potentially reports on flow of fatty acids from the adipocytes during lipolysis.”