Conditional Suppression of Cellular Genes: Lentivirus Vector-Mediated Drug-Inducible RNA Interference

By M. Wiznerowicz, Didier Trono. Journal of Virology, 2003

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MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells. (2008, unknown): “were performed, as previously published (30).”
Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression (2007, methodology): “pLenti6–control miRNA and pLenti6– JMJD2C miRNA1 were used to produce recombinant lentiviruses to infect LNCaP cells as previously describe”
HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity. (2007, unknown): “To further control any differences between the experimental and control injected cells, we rendered LV-shSMOH silent and conditionally inducible by treatment with doxycycline (DOX) through co-transduction with LV-tTR-KRAB ( 14 ).”
A Versatile Viral System for Expression and Depletion of Proteins in Mammalian Cells (2009, background): “Several laboratories and companies have therefore developed viral vectors for the delivery of cDNAs and/or shRNAs or miRNAs to a wide variety of cells [6,7,8,9,10,11,12,13,14,15,16].”