Identification of bronchioalveolar stem cells in normal lung and lung cancer.

By Carla F. Kim, E. Jackson, Amber Woolfenden, Sharon Lawrence, I. Babar, Sinae A. Vogel, D. Crowley, R. Bronson, T. Jacks. Cell, 2005

2,186 citations recorded by the source corpus.

Subfields: Oncology, Pulmonary and Respiratory Medicine, Surgery

View Paper: https://www.semanticscholar.org/paper/f4397a658a84e51e31ee2335c29c58d95a40c188

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Oncology

1. Jane E. Visvader
2. J. Massagué
3. J. Dick
4. Hans Clevers
5. M. Wicha
6. D. Nguyen
7. Suling Liu
8. G. Dontu

In Pulmonary and Respiratory Medicine

1. B. Hogan
2. Hans Clevers
3. J. Rock
4. E. Morrisey
5. P. Noble
6. Brigham C. Willis
7. J. Massagué
8. Marc Ladanyi

In Surgery

1. B. Hogan
2. Hans Clevers
3. Alec C. Kimmelman

Citations in the corpus

• Cells of origin in cancer (2011, background): “Bronchioalveolar stem cells (BASCs) have been implicated as the cell of origin for lung adenocarcinomas induced by mutant Kras”
• Targeting of CD44 eradicates human acute myeloid leukemic stem cells (2006, background): “Recent studies have demonstrated that, like AML, solid tumors retain only a small number of malignant cancer stem cells with the inherent capacity to initiate the tumor and maintain growth of the phenotypically and functionally heterogeneous malignant clon”
• Genetics and biology of pancreatic ductal adenocarcinoma. (2006, background): “…between endocrine and acinar cells seems to be regulated by the activity of TGF- family members (for review, see Kim and Hebrok 2001), and more recent studies have demonstrated a role for Wnt signaling in pancreatic development (Dessimoz et al. 2005; H.J. Kim et al. 2005; Murtaugh et al. 2005).”
• Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition (2011, methodology): “To address this possibility, we used our previously described Scgb1a1CreER knock-in allele that is normally expressed in bronchiolar Clara cells, including the few Scgb1a1;Sftpc dual positive cells in the bronchioalveolar duct junction [putative bronchioalveolar stem cells (BASCs)] (40) and a popula”
• Identification of DOK family genes as lung tumor suppressors (2010, neutral): “In this regard, BASCs have been identified as putative stem cells in the mouse lung that are associated with adenocarcinoma developmen”
• Cancer stem cells: an old idea--a paradigm shift. (2006, background): “have developed an animal model that targets normal lung stem cells to produce adenocarcinomas that resemble those found in human lung cancers (39).”
• TGF-β-induced EMT: mechanisms and implications for fibrotic lung disease (2007, background): “, pluripotent subpopulations recently identified as “bronchoalveolar stem cells” (43)], is currently unknown but warrants further elucidation.”
• Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells. (2007, background): “Recent data from a mouse model reinforce the notion that lung adenocarcinoma arises from stem cells in the terminal bronchioles ( 6 ).”
• Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. (2006, background): “However, the true relatedness of previously reported TSCs to normal stem cells and their exact relevance to our current in vitro and in vivo models of cancer, as well as to primary human tumors in situ, remain unclear (Dontu et al., 2003; Huntly and Gilliland, 2005; Kim et al., 2005; Pardal et al., ”
• Cancer stem cells: models and concepts. (2007, background): “Several mouse models for the study of CSC biology in epithelial solid tumors are also currently being investigated, including models for lung (48) and prostate (67) cancer.”