Targeting of CD44 eradicates human acute myeloid leukemic stem cells

By Liqing Jin, Kristin J. Hope, Q. Zhai, F. Smadja-joffe, J. Dick. Nature Medicine, 2006

1,242 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/fd2620308772daefd296dd1457f7a242fb1782f0

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Citations in the corpus

Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatment (2018, background): “Concomitantly, the expression of sonic hedgehog (SHH) and glioma-associated oncogene homolog 1 (GLI1), the well-known signaling pathway molecules involved in the drug resistance, is higher in enriched CD44+/Musashi-1+ gastric cancer stem cells and consequently enhances the drug resistance via high d”
Identification of Gastric Cancer Stem Cells Using the Cell Surface Marker CD44 (2009, background): “Several recent studies suggest that CD44 ablation in some types of murine (as well as human) cancers significantly reduced tumor induction [37–39].”
The therapeutic promise of the cancer stem cell concept. (2010, background): “Interference with cancer cell transport to stem cell–supportive microenvironmental niches was found to represent an additional mechanism underlying CD44-specific Ab–mediated AML CSC eradication, indicating a role for the microenvironment in regulating CSC function (123).”
Cancer stem cells: current status and evolving complexities. (2012, background): “There has been considerable interest in the development of monoclonal antibodies to target CSCs. Markers differentially expressed between normal stem cells and LSCs have been utilized to specifically target LSCs in human AML, including CD44 (Jin et al., 2006), IL3R (Jin et al., 2009), and the immuno”
MLL translocations, histone modifications and leukaemia stem-cell development (2007, background): “Furthermore, as evidence accumulates that LSCs express cell-surface antigens that are not expressed on HSCs, the potential for monoclonal antibody-based therapeutics improve”
Tumour-initiating cells: challenges and opportunities for anticancer drug discovery (2009, background): “A mAb specific for the adhesion molecule CD44 was shown to eradicate human AML-initiating cells in vivo by blocking the trafficking of leukaemia-initiating cells to supportive microenvironments, and by altering their 'stem cell' fate through differentiatio”
INHIBITION OF MITOCHONDRIAL TRANSLATION AS A THERAPEUTIC STRATEGY FOR HUMAN ACUTE MYELOID LEUKEMIA (2011, methodology): “Xenotransplantation in NOD/SCID mice is a robust model system to assay stem cells and test the efficacy of antileukemia therapies in vivo (Bonnet and Dick, 1997; Jin et al., 2006; Lapidot et al., 1994).”
New technologies for human cancer imaging. (2008, background): “Acute Leukemia Recent evidence points to a so-called stem-cell niche in the bone marrow that is required for sustenance of acute leukemia.(85) Although the bone marrow is well vascularized, which aids in contrast agent biodistribution to the target cells, the small number of malignant and normal cel”
Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region (2007, background): “Recently, a cell-surface marker, CD44, was reported to be important both in mouse and human LS-cell homing and engraftmen”