Endogenous siRNAs Derived from Transposons and mRNAs in Drosophila Somatic Cells

By Megha Ghildiyal, Hervé Seitz, M. Horwich, Chengjian Li, T. Du, Soohyun Lee, Jia Xu, E. Kittler, M. Zapp, Zhiping Weng and 1 more. Science, 2008

706 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/f423ad1f26142f1223b1843197c6e44b54e14583

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Citations in the corpus

Differentiating Protein-Coding and Noncoding RNA: Challenges and Ambiguities (2008, background): “To further confound this dichotomy, recent studies show that mRNAs that form duplex RNA structures within themselves, or with other antisense RNAs or pseudogenes, may be processed into endogenous siRNAs, therefore providing mRNAs with an additional fate [66–68].”
Transposition Driven Genomic Heterogeneity in the Drosophila Brain: A Dissertation (2012, neutral): “, 2010) and posttranscriptional mechanisms (Vagin et al., 2006; Yang and Kazazian, 2006; Brennecke et al., 2008; Ghildiyal et al., 2008; Kawamura et al., 2008; Chung et al., 2008; Czech et al., 2008) to suppress the expression and disruptive activity of “parasitic” transposable elements that compris”
Non‐coding RNAs: regulators of disease (2010, background): “Although exogenous siRNAs were discovered a decade ago, endogenous siRNAs (endosiRNAs) have only recently been identified in fruitflies and mammals [50–58], where their biogenesis is dependent on Dicer processing of duplexes formed by overlapping transcripts or long perfect hairpin structures.”
Small RNAs in transcriptional gene silencing and genome defence (2009, background): “These precursors include sense and antisense RNAs transcribed from convergent promoters, which can anneal to form dsRNA, and hairpin RNAs that result from transcription through inverted repeat region”
Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs. (2008, background): “Such tailed mirtrons were also suggested recently based on small RNA sequences from developing chicks, although their biogenesis was not evaluated (Glazov et al. 2008).”
PIWI-interacting small RNAs: the vanguard of genome defence (2011, background): “melanogaster somatic cells that lack the piRNA pathwa”
Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (2010, methodology): “…populations might drive our reprogramming effect, we characterized by high-throughput sequencing the small (19–35 bp) RNA population from control and low-protein offspring livers (Ghildiyal et al., 2008) and mapped reads to known miRNAs (Table S4). cember 23, 2010 ª2010 Elsevier Inc. 1087 Figure 3.”
Filtering of deep sequencing data reveals the existence of abundant Dicer-dependent small RNAs derived from tRNAs. (2009, background): “The common feature of these siRNAs is that their processing is not dependent on Drosha and DGCR8 (Babiarz et al. 2008; Ghildiyal et al. 2008).”
Long noncoding RNAs: functional surprises from the RNA world. (2009, background): “Like pseudogenes, some natural antisense transcripts (NATs) are able to hybridize to overlapping genes and generate endo-siRNAs (Czech et al. 2008; Ghildiyal et al. 2008; Okamura et al. 2008; Watanabe et al. 2008).”
Diversity and dynamics of the Drosophila transcriptome (2014, positive): “Cis-NAT-siRNA production typically involves convergent transcription units that overlap on their 3' ends, but other documented loci generate siRNAs across internal exons, introns or 5'UTRs 37,38,39 .”