ExoCarta: A web-based compendium of exosomal cargo

By Shivakumar Keerthikumar, David Chisanga, D. Ariyaratne, Haidar Al Saffar, Sushma Anand, Kening Zhao, Monisha Samuel, Mohashin Pathan, M. Jois, Naveen K. Chilamkurti and 2 more. Journal of Molecular Biology, 2015

1,280 citations recorded by the source corpus.

Exosomes are membranous vesicles that are released by a variety of cells into the extracellular microenvironment and are implicated in intercellular communication. As exosomes contain RNA, proteins and lipids, there is a significant interest in characterizing the molecular cargo of exosomes. Here, we describe ExoCarta (http://www.exocarta.org), a manually curated web-based compendium of exosomal proteins, RNAs and lipids. Since its inception, the database has been highly accessed (>54,000 visitors from 135 countries). The current version of ExoCarta hosts 41,860 proteins, >7,540 RNA and 1,116 lipid molecules from more than 286 exosomal studies annotated with ISEV minimal experimental requirements for definition of extracellular vesicles. Besides, ExoCarta features dynamic protein-protein interaction networks and biological pathways of exosomal proteins. Users can download most often identified exosomal proteins based on the number of studies. The downloaded files can further be imported directly into FunRich (http://www.funrich.org) tool for additional functional enrichment and interaction network analysis.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/473d8411edda0124c5d6f99f2ebb516c8b43f1ed

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Molecular Biology

Citations in the corpus

Vesiclepedia 2019: a compendium of RNA, proteins, lipids and metabolites in extracellular vesicles (2018, methodology): “Compared to the exosomal database ExoCarta (11), Vesi-clepedia (http://www.microvesicles.org) is a compendium that catalogues proteins, RNAs, lipids and metabolites that are identified in all classes of EVs (12).”
The biology, function, and biomedical applications of exosomes (2020, positive): “Exosomes can contain membrane proteins, cytosolic and nuclear proteins, extra-cellularmatrixproteins,metabolites,andnucleic acids,namelymRNA,noncodingRNAspecies, andDNA( 18 – 21 ) (Fig.”
Expansion of the Gene Ontology knowledgebase and resources (2016, methodology): “The ExoCarta and Vesiclepedia databases (6,7) have started to use the revised ontology, and are collaborating with the GOC to include their annotations in the GO database.”
High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources (2016, background): “Traditional exosome markers CD81 and CD9 (41) were enriched in both exosomes and MVs, with level of enrichment being higher in exosomes (Fig.”
Targeting Tumor Microenvironment for Cancer Therapy (2019, background): “and cytosolic proteins, miRNAs and mRNAs, cytokines, chemokines, growth factors and other signaling molecules [125].”