ExoCarta as a resource for exosomal research

By Richard J. Simpson, Hina Kalra, Suresh Mathivanan. Journal of Extracellular Vesicles, 2012

359 citations recorded by the source corpus.

Exosomes are a class of extracellular vesicles that are secreted by various cell types. Unlike other extracellular vesicles (ectosomes and apoptotic blebs), exosomes are of endocytic origin. The roles of exosomes in vaccine/drug delivery, intercellular communication and as a possible source of disease biomarkers have sparked immense interest in them, resulting in a plethora of studies. Whilst multidimensional datasets are continuously generated, it is difficult to harness the true potential of the data until they are compiled and made accessible to the biomedical researchers. Here, we describe ExoCarta (http://www.exocarta.org), a manually curated database of exosomal proteins, RNA and lipids. Datasets currently present in ExoCarta are integrated from both published and unpublished exosomal studies. Since its launch in 2009, ExoCarta has been accessed by more than 16,000 unique users. In this article, we discuss the utility of ExoCarta for exosomal research and urge biomedical researchers in the field to deposit their datasets directly to ExoCarta.

Subfields: Biomedical Engineering, Materials Chemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/daaf9dae9fa205c61aeed97bd4eb4e92cfd86e31

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Citations in the corpus

Tetraspanins in Extracellular Vesicle Formation and Function (2014, result): “According to most recent proteomic results gathered in the ExoCarta and EVPedia databases (54, 55), exosomes have a defined protein signature, comprising conserved as well as cell type specific sets of exosomal proteins.”
Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation (2012, neutral): “Described initially in 2009 [32], the database has been visited by more than 16,000 unique users [33].”
ExoCarta: A web-based compendium of exosomal cargo (2015, neutral): “2A) giving rise to multidimensional data [1, 16].”
Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake (2016, neutral): “Three different databases are publicly accessible: Exocarta, Vesiclepedia, and EVpedia (Kim et al. 2013; Kalra et al. 2012; Mathivanan and Simpson 2009; Simpson et al. 2012; Mathivanan et al. 2012 ).”
Optimized exosome isolation protocol for cell culture supernatant and human plasma (2015, background): “This was also seen when the abundance of the canonical exosome protein Flotillin-1 (9,10) was assessed (Fig.”
Focus on Extracellular Vesicles: Introducing the Next Small Big Thing (2016, background): “org), a community annotation compendium for all EVs [130], have allowed researchers to successively deposit identified constituents of exosomes and provide a general overview of their molecular composition [127].”
Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function (2015, background): “As described above, a wide variety of molecules are contained in exosomes, including proteins, lipids, DNAs, mRNAs, and miRNAs, which are recorded in the ExoCarta database [50].”
EVpedia: an integrated database of high-throughput data for systemic analyses of extracellular vesicles (2013, background): “For example, many mass spectrometry-based proteomic studies, microarray or next-generation sequencing-based transcriptomic studies, (16,17), which was recently updated into Vesiclepedia (http://www.microvesicles.org; 18).”