Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex.

By Rita Z. Goldstein, Nora D. Volkow. American Journal of Psychiatry, 2002

2,642 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Epidemiology

View Paper: https://www.semanticscholar.org/paper/f3dd8b9b6c70895f1c425031bd888ecc241bcd61

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Citations in the corpus

Dysfunction of ventral striatal reward prediction in schizophrenia (2006, background): “Ventral striatal activity has been associated with pleasant emotions of anticipation (Berridge and Robinson, 1998), and ventral striatal dysfunction has long been associated with reduced motivation or anhedonia (Goldstein and Volkow, 2002; Wise, 1982).”
The addicted human brain: insights from imaging studies. (2003, background): “The inhibition of topdown control would release behaviors that are normally kept under close monitoring and would simulate stress-like reactions in which control is inhibited and stimulus-driven behavior is facilitated (45).”
Structural Abnormalities in the Brains of Human Subjects Who Use Methamphetamine (2004, positive): “…, in light of the role of the cingulate gyrus in inhibitory control and deficits in performance of tasks that require such control in MA abusers ( Goldstein and Volkow , 2002 ) , the struc - tural abnormalities reported here , paired with the metabolic ab - normalities ( in the perigenual ,…”
Understanding the construct of impulsivity and its relationship to alcohol use disorders (2010, methodology): “Many different measures of impulsivity have been employed in human studies, using both questionnaire and laboratory-based tasks.”
Overlapping neuronal circuits in addiction and obesity: evidence of systems pathology (2008, background): “Since OFC, CG and DLPFC are involved with inhibitory control (Goldstein & Volkow 2002) and with emotional processing (Phan et al. 2002), we had postulated that their improper regulation by DA in addicted subjects could underlie their loss of control over drug intake and their poor emotional…”
Drug Addiction as a Pathology of Staged Neuroplasticity (2008, background): “In particular, this involves identifying changes in glutamate transmission and the emergence of the hypofrontality that permits drug-seeking to proceed without conscious interventions (Jentsch and Taylor, 1999; Goldstein and Volkow, 2002).”
The Neurocircuitry of Impaired Insight in Drug Addiction (2009, positive): “In the current opinion article, we argue that as a cognitive disorder [ 5 ], drug addiction might share with these neuropsychiatric disorders similar abnormalities in selfawareness and behavioral control that can be attributed to an underlying neural dysfunction.”
Neurocircuitry of Addiction (2009, background): “Addiction also entails perturbations in cortically regulated cognitive and emotional processes, which cause the overvaluing of drug reinforcers at the expense of the undervaluing of natural reinforcers, and deficits in inhibitory control of drug responses (Goldstein and Volkow, 2002).”
Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse (2003, background): “, and a variety of data indicate that corticolimbic circuitry, including the glutamatergic projection from the prefrontal cortex to the nucleus accumbens, mediates reinstatement in experimental animals and craving in cocaine addict”
The addicted human brain viewed in the light of imaging studies: brain circuits and treatment strategies. (2004, background): “Inhibitory control is regulated by several brain regions , including anterior CG as well as lateral OFC , which ( as outlined above ) are disrupted in addicted subjects ( Goldstein and Volkow , 2002 ) .”
Pro v Con Reviews: Is Food Addictive? (2012, background): “In addition, because impairments in OFC and ACC are associated with compulsive behaviours and impulsivity, DA’s impaired modulation of these regions is likely to contribute to the compulsive and impulsive drug intake seen in addiction (76).”
The Neuroscience of Drug Reward and Addiction. (2019, positive): “…reasonable to hypothesize that faulty modulation of these regions by striatal D2R is likely to underlie the enhanced motivational value of drugs, the signiﬁcant loss of control over drug intake among addicted individuals (335), and the compulsive and impulsive drug intake seen in addiction (129).”