Time restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high fat diet

By Megumi Hatori, Christopher Vollmers, Amir Zarrinpar, Luciano DiTacchio, E. Bushong, S. Gill, Mathias Leblanc, A. Chaix, Matthew S. Joens, J. Fitzpatrick and 2 more. Cell Metabolism, 2012

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SUMMARY While diet-induced obesity has been exclusively attributed to increased caloric intake from fat, animals fed high fat diet (HFD) ad libitum (ad lib) eat frequently throughout day and night disrupting the normal feeding cycle. To test whether obesity and metabolic diseases result from HFD or disruption of metabolic cycles, we subjected mice to either ad lib or time restricted feeding (tRF) of a HFD for 8 h/day. Mice under tRF consume equivalent calories from HFD as those with ad lib access, yet are protected against obesity, hyperinsulinemia, hepatic steatosis, inflammation, and have improved motor coordination. The tRF regimen improved CREB, mTOR and AMPK pathway function and oscillations of the circadian clock and their target genes' expression. These changes in catabolic and anabolic pathways altered liver metabolome, improved nutrient utilization and energy expenditure. We demonstrate in mice that tRF regimen is a non-pharmacological strategy against obesity and associated diseases.

Subfields: Endocrine and Autonomic Systems, Physiology

View Paper: https://www.semanticscholar.org/paper/a974ec493b0f054126aa02678db6f1504d1f8230

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In Endocrine and Autonomic Systems

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Citations in the corpus

A smartphone app reveals erratic diurnal eating patterns in humans that can be modulated for health benefits (2015, background): “Unlike mice, where reducing the eating duration to 10 hr does not alter total caloric intake (Hatori et al., 2012), our human intervention cohort reduced the estimated daily caloric intake (average reduction 20.26%; 95% CI 4.92%–35.6%; paired t test p < 0.05).”
Timing of food intake predicts weight loss effectiveness (2013, background): “Of interest are the animal studies indicating that reversal of the feeding rhythm causes adverse metabolic effects and that correcting the timing of food intake can even prevent metabolic disturbances in animals on a high-fat diet (10, 11, 37).”
Impact of insufficient sleep on total daily energy expenditure, food intake, and weight gain (2013, result): “Our findings add to the growing body of evidence from epidemiological (26) and nonhuman models (27, 28) that indicate that overeating at night may contribute to weight gain.”
Reprogramming of the Circadian Clock by Nutritional Challenge (2013, neutral): “Hepatic circadian rhythmicity in particular, is highly responsive to cyclic energy intake (Hatori et al., 2012; Pendergast et al., 2013; Vollmers et al., 2009).”
Impact of intermittent fasting on health and disease processes (2016, neutral): “…c a i t c t l D i s n t a fi c t o a t i e d t o t w r f 2 r ( r c T r n i a e d h T ARTICLERR-717; No. of Pages 13 M.P. Mattson et al. / Ageing Re REB, BDNF and autophagy pathways (Descamps et al., 2005; Cheng t al., 2012, 2016; Hatori et al., 2012; Longo and Mattson, 2014; uen and Sander, 2014).”
Flipping the Metabolic Switch: Understanding and Applying Health Benefits of Fasting (2017, background): “Mice fed a high-fat diet ad libitum develop obesity, elevated plasma glucose, insulin and leptin levels, and impaired glucose tolerance; TRF mostly normalizes these adverse effects of the high-fat diet (61,65).”
Diet dominates host genotype in shaping the murine gut microbiota (2014, background): “Rapid restructuring of the gut microbiota may contribute to the beneficial effects of time-restricted feeding (Hatori et al., 2012) and could broadly alter the microbial contributions toward metabolism and immunity.”
Promoting Health and Longevity through Diet: from Model Organisms to Humans (2015, positive): “An isocaloric reduction of fat intake only during the night is sufficient to prevent obesity in these animals (Hatori et al., 2012), suggesting that altered meal pattern alone could be used to prevent certain metabolic diseases (Garaulet et al., 2013; Jakubowicz et al., 2013).”
Bile Acid Signaling in Metabolic Disease and Drug Therapy (2014, background): “Fasting and refeeding as well as the time of feeding have profound effects on circadian rhythms of hepatic lipid and glucose metabolism (Vollmers et al., 2009; Asher and Schibler, 2011; Hatori et al., 2012; Tong and Yin, 2013).”