The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

By Kate Schroder, Rongbin Zhou, J. Tschopp. Science, 2010

1,139 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f398ab68ecc63098474e9ee9fb509eb3fcd4e64e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Rongbin Zhou
2. J. Tschopp
3. M. Donath

In Molecular Biology

1. J. Tschopp
2. C. Deutschman
3. Rongbin Zhou
4. M. Donath
5. Greta Guarda
6. Aubry Tardivel
7. Wei Jiang
8. T. Simmet

Citations in the corpus

• Sepsis: current dogma and new perspectives. (2014, background): “Inflammasomes mediate the release of HMGB1, IL1b, and IL-18, which are secreted into the extracellular space and function to amplify the innate immune response (Lu et al., 2012; Lamkanfi et al., 2010; Schroder et al., 2010).”
• Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome. (2016, background): “Here, we unveil a pivotal unexpected target of TGR5 signaling and suggest that pharmacological intervention in TGR5 signaling aiming at the critical control point of the NLRP3-related pro-inflammatory milieu might hold therapeutic promise for T2D.”
• Type 2 diabetes as an inflammatory disease (2011, background): “It remains possible that the inflammasome may act as a sensor of metabolic dange”
• Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome (2012, background): “The diversity of NLRP3-activating stimuli suggests that these compounds trigger cellular intermediates that couple to NLRP3 (refs”
• Inflammation and its role in age-related macular degeneration (2016, background): “by NLRs, leading to the maturation and secretion of these cytokines after inflammasome assembly and caspase-1-mediated proteolysis [37].”
• The inflammasomes. (2010, neutral): “Domains are classified according tothe NCBI domain annotation tool for the longest human protein product, with the exception of the FIIND domain that was identified independently of NCBI (Tschopp et al., 2003).”
• NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases (2015, background): “…LRR, leucine-rich-repeat olymorphonuclear leukocytes; POP, PYD-only proteins; PRRs, pattern-recognition MCs, smooth muscle cells; TLRs, toll-like receptors; TNF, tumor necrosis factor; Trx, unfolded protein response eing Biology (B2A), UMR-8256/INSERM ERL-1164, Université Pierre et Marie Curie,”
• Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities (2011, neutral): “Owing to the importance of oxidative stress to inflammatory pathways (317), several studies have analyzed atherogenic susceptibility in GPx-1-deficient mice.”