Genetic, biochemical, and clinical features of chronic granulomatous disease.

By B. Segal, T. Leto, J. Gallin, H. Malech, S. Holland. Medicine, 2000

910 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f305b2b283d1f918eb4cbde8c7f3ddc69bdeee22

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. C. Winterbourn
2. M. Hampton
3. A. Kettle
4. W. Nauseef
5. S. Klebanoff
6. D. Brenner
7. T. Kuijpers
8. P. Nagy

In Molecular Biology

1. C. Winterbourn
2. M. Hampton
3. D. Brenner
4. W. Nauseef
5. A. Kettle
6. S. Klebanoff
7. P. Nagy
8. Navdeep S. Chandel

Citations in the corpus

• How human neutrophils kill and degrade microbes: an integrated view (2007, background): “The significant morbidity secondary to infection in patients with CGD provides a dramatic demonstration of the importance of the NADPH oxidase for normal host defense (26, 143).”
• Reactive Oxygen Species and Neutrophil Function. (2016, background): “Although defective killing cannot account for all of the problems associated with CGD, isolated neutrophils that lack NOX2 activity kill a wide range of microorganisms poorly, and this is a major contributor to the disease (56).”
• Biotechnological Applications of Acetic Acid Bacteria (2008, neutral): “Sievers, M., Gaberthüel, C., Boesch, C., Ludwig, W., and Teuber, M. 1995.”
• Chronic Granulomatous Disease: The European Experience (2009, background): “This renders it difficult for clinicians to inform CGD patients and their parents what to expect, and to find a proper balance between risks, costs and benefits of various treatments, ranging from long-term prophylactic antibiotic medication to stem cell transplantation and gene therapy [4].”
• Myeloperoxidase: friend and foe (2005, neutral): “[78, 79, 97, 98]).”
• Liver inflammation and fibrosis. (2017, background): “NOX2 induces the oxidative burst required by neutrophils to kill pathogenic bacteria (109), while NOX1 and NOX4 are expressed in hepatocytes, Kupffer cells, and hepatic stellate cells (108).”
• Myeloperoxidase: a front‐line defender against phagocytosed microorganisms (2013, background): “Neutrophils from patients with CGD, which lack a functional NADPH oxidase, kill many microbial species poorly, and patients with the condition suffer from life-threatening infections [50, 51].”