Translational control in the endoplasmic reticulum stress response.

By D. Ron. Journal of Clinical Investigation, 2002

887 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology

View Paper: https://www.semanticscholar.org/paper/f2adef05faa5822abde4f1865e78d1fd76dc85a9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. R. Kaufman
2. D. Ron
3. J. Malhotra
4. Afshin Samali
5. A. Gorman
6. H. Harding
7. G. Hotamışlıgil
8. F. Urano

In Epidemiology

1. R. Kaufman
2. J. Malhotra
3. D. Ron
4. Afshin Samali
5. A. Gorman
6. H. Harding
7. P. Newsome
8. J. Tomlinson

Citations in the corpus

• ER stress‐regulated translation increases tolerance to extreme hypoxia and promotes tumor growth (2005, background): “This pathway, known as the integrated stress response (ISR) (Ron, 2002), constitutes one arm of a larger coordinated program called the unfolded protein response (UPR), which facilitates the cell to adapt to ER stress.”
• Endoplasmic Reticulum Stress and Oxidative Stress: A Vicious Cycle or a Double-Edged Sword? (2007, positive): “:3) is the activating transcription factor 4 (ATF4) (43, 44, 114, 121).”
• Translational control in stress and apoptosis (2005, background): “, whereas PERK is activated in response to ER stres”
• Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals (2017, background): “…protein synthesis while allowing preferential translation of some transcription factors that have upstream ORFs in their 5′ UTRs, like ATF4 and ATF5 (Ron, 2002; Pakos-Zebrucka et al., 2016). eIF2α can be phosphorylated by four kinases, each of which is activated by different forms of cellular…”
• The integrated stress response (2016, positive): “The common point of convergence for all the stress stimuli that activate ISR is phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 (eIF2a) on serine 51 [1].”
• Pathogenesis of non-alcoholic fatty liver disease (2009, positive): “25 ER stress can be caused by a variety of biological stresses, including hyperinsulinaemia and hyperlipidaemia, 25,78 and can result in activation of various pathways leading to IR, inflammation, apoptosis and mitochondrial dysfunction.”
• The endoplasmic reticulum and the unfolded protein response. (2007, background): “Paradoxically, eIF2α phosphorylation induces translation of ATF4 mRNA.”
• Cardiotoxicity of the cancer therapeutic agent imatinib mesylate (2006, background): “Because of the pronounced accumulation of membranous debris within, and dilation of, the sarcoplasmic and endoplasmic reticulum in the hearts of imatinib-treated humans and mice, we tested whether the ER stress response pathwa”
• Autophagy Is Activated for Cell Survival after Endoplasmic ReticulumStress (2006, background): “The UPR involves at least three distinct components, namely transcriptional induction of genes encoding ER-resident chaperones to facilitate protein folding, translational attenuation to decrease the demands made on the organelle, and ER-associated degradation (ERAD) to degrade the unfolded proteins”
• ER stress triggers apoptosis by activating BH3-only protein Bim. (2007, background): “ER stress can be provoked by a variety of patho-physiological conditions, such as ischemia, viral infection, or mutations that impair resident/secretory protein folding (Ron, 2002) and has been implicated as an initiator or contributing factor in a range of diseases, including liver cirrhosis or typ”