Autophagy Is Activated for Cell Survival after Endoplasmic ReticulumStress

By Maiko Ogata, S. Hino, Atsushi Saito, Keisuke Morikawa, S. Kondo, Soshi Kanemoto, Tomohiko Murakami, M. Taniguchi, I. Tanii, K. Yoshinaga and 4 more. Molecular and Cellular Biology, 2006

1,863 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology

View Paper: https://www.semanticscholar.org/paper/9c566718b17ef1d5ec22ac0c47f948b2c8abed89

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. D. Klionsky
2. N. Mizushima
3. Beth Levine
4. Guido Kroemer
5. C. Hetz
6. G. Hotamışlıgil
7. Y. Ohsumi
8. T. Yoshimori

In Epidemiology

1. Beth Levine
2. Guido Kroemer
3. N. Mizushima
4. D. Klionsky
5. I. Slaninová
6. Douglas R. Green
7. L. Galluzzi
8. G. Hotamışlıgil

Citations in the corpus

• Ubiquitination and selective autophagy (2012, background): “As a consequence, reducing ER volume is followed by decreasing unfolded ER proteins, though the molecular mechanisms remain elusive.(99,100)”
• JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. (2008, background): “…receptor activation, growth factor withdrawal, cytokine stimulation (e.g., IL-2 and TNFa), caspase inhibition, and treatment with neuronal excitotoxic stimuli (Borsello et al., 2003; He and Orvedahl, 2007; Jia et al., 2006; Li et al., 2006; Lu et al., 2007; Ogata et al., 2006; Yu et al., 2004).”
• The endoplasmic reticulum stress response in immunity and autoimmunity (2008, background): “This might allow cells to adapt to stress by initiating autophagy”
• Mitochondria supply membranes for autophagosome biogenesis during starvation (2010, background): “, 2008) form CFP-LC3 positive structures, consistent with other reports of ER stress induced autophagy (Ogata et al., 2006; Sakaki et al., 2008).”
• Regulation Mechanisms and Signaling Pathways of Autophagy (2009, background): “One downstream target of IRE1 is c-Jun N-terminal kinase (JNK), which is essential for lipid conjugation of LC3 induced by tunicamycin or by accumulation of cytosolic misfolded proteins due to proteasome inhibition in MEFs and cancer cells (24,106).”
• ER stress-induced cell death mechanisms. (2013, background): “demonstrated that ER stress-induced autophagy is regulated by IRE1α interaction with TRAF2 to regulate JNK activation [58].”
• Self-eating and self-killing: crosstalk between autophagy and apoptosis (2007, background): “In one study, it was found that MEFs that lack IRE1α (but not those that lack PERK or ATF6) were unable to mount an autophagic response to ER stres”
• Cellular Stress Responses: Cell Survival and Cell Death (2010, background): “Autophagy is typically observed in cells that are exposed to a variety of metabolic and therapeutic stresses, including growth factor deprivation, inhibition of the receptor tyrosine kinase/Akt/ mammalian target of rapamycin (mTOR) signaling, shortage of nutrients, ischemia/reperfusion, inhibition o”
• Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance (2010, background): “, 2009) and that experimental ER stress can induce autophagy in mammalian cells (Ogata et al., 2006), with several canonical UPR (unfolded protein response) pathways implicated in this interaction (Kouroku et al.”