Mitotic clonal expansion: A synchronous process required for adipogenesis

By Q. Tang, Tamara C. Otto, M. Lane. Proceedings of the National Academy of Sciences of the United States of America, 2002

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Transcriptional control of adipocyte formation. (2006, background): “Inhibition of cell proliferation with drugs that block S phase prevents adipogenesis, and it has therefore been suggested that adipogenesis requires mitosis to reorganize chromatin to facilitate induction of the adipogenic genes (Tang et al., 2003).”
The role of FoxO in the regulation of metabolism (2008, background): “Almost immediately upon hormonal induction, there is an increase in the expression of G1 cyclins as well as a decrease in cyclin-dependent kinase inhibitors, including p21, events that trigger progression from G1 to S phase (Morrison and Farmer, 1999; Tang et al., 2003).”
Adipogenesis: from stem cell to adipocyte. (2012, background): “Thus, C/EBPβ−/− MEFs fail to undergo mitotic clonal expansion and do not differentiate into adipocytes, while C/EBPβ−/− MEFs undergo mitotic clonal expansion and differentiate normally (89, 92).”