Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis.

By P. Fernandez-Marcos, Johan Auwerx. American Journal of Clinical Nutrition, 2011

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PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism (2020, background): “PGC-1α is regulated at both the transcriptional and post-translational levels [15].”
The hallmarks of aging. (2013, background): “PGC-1α orchestrates a complex metabolic response that includes mitochondriogenesis, enhanced anti-oxidant defenses, and improved fatty acid oxidation (Fernandez-Marcos and Auwerx, 2011).”
Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling (2014, background): “PGC-1a, a master regulator of mitochondrial biogenesis and function, acts as a cold-inducible protein that controls adaptive thermogenesis in BAT, and its expression is regulated by the activation of cAMP/PKA/p38 MAPK signaling pathways (35,36).”
Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging (2013, background): “Under conditions of low energy, AMPK-mediated ell 155, 1624–1638, December 19, 2013 ª2013 Elsevier Inc. 1631 A B C D E F G H I J K L M N O (legend on next page) 1632 Cell 155, 1624–1638, December 19, 2013 ª2013 Elsevier Inc. phosphorylation of PGC-1a allows it to be deacetylated and activated by SIR”