Surviving the breakup: the DNA damage checkpoint.

By Jacob C. Harrison, J. Haber. Annual Review of Genetics, 2006

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Oxidative Stress Resistance in Deinococcus radiodurans (2011, background): “coli (73) or the ATM (ataxia telangiectasia, mutated)- and ATR (ATM and Rad3 related)initiated DNA damage checkpoint in eukaryotes (240).”
The impact of a negligent G2/M checkpoint on genomic instability and cancer induction (2007, background): “Their mutation prevents RAD53 (the yeast homologue of CHK2 ) inactivation and cell cycle re-entry in the presence of unrepaired damage, demonstrating that adaptation is a defined, genetically-regulated proces”
DNA damage checkpoints: from initiation to recovery or adaptation. (2007, background): “seemed unlikely that the cells of higher eukaryotes, including humans, could also undergo this process [53].”
A vertebrate gene, ticrr, is an essential checkpoint and replication regulator. (2010, background): “This has established the PIKK kinases, ATM and ATR, as playing a central role in DNA damage response (Harrison and Haber 2006).”
Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double strand break ends (2008, positive): “Ddc2/Mec1 is required for DNA-damage checkpoint arrest (reviewed in Harrison and Haber, 2006), binds to RPA-coated ssDNA, and was shown previously to localize to DNA-damage foci (Melo et al., 2001).”