Overexpression of Long Non-coding RNA HOTAIR Predicts Tumor Recurrence in Hepatocellular Carcinoma Patients Following Liver Transplantation

By Zhe Yang, Lin Zhou, Li-ming Wu, Ming-chun Lai, Haiyang Xie, Feng Zhang, Shu-sen Zheng. Annals of Surgical Oncology, 2011

712 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/f34d0e02a61fe8de11ecb51626578bf9a0f5f741

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Xing Chen
2. Howard Y. Chang
3. Zhuhong You
4. John S. Mattick
5. Johannes Rinn
6. Guiying Yan
7. Marcel E. Dinger
8. Chenggang Clarence Yan

In Molecular Biology

1. Xing Chen
2. Howard Y. Chang
3. Zhuhong You
4. Johannes Rinn
5. John S. Mattick
6. Marcel E. Dinger
7. Guiying Yan
8. Chenggang Clarence Yan

Citations in the corpus

• Genome regulation by long noncoding RNAs (2012, background): “Elevated HOTAIR level is also predictive of metastasis or progression in colon and liver cancers, suggesting a general oncogenic trait (120, 121).”
• LncRNADisease: a database for long-non-coding RNA-associated diseases (2012, background): “The up-regulation of the lncRNA HOTAIR is an independent prognostic factor of tumor recurrence in hepatocellular carcinoma patients after liver transplantation (15).”
• Long Noncoding RNAs: Past, Present, and Future (2013, background): “…called interchromatin granules that usually cluster around nuclear speckles; in the absence of signal, Cbx4 becomes methylated and instead binds another lncRNA TUG1, associates with corepressors such as Ezh2, and translocates to silencing compartments called Polycomb bodies (L. Yang et al. 2011).”
• Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer (2016, background): “breast cancer [12], colorectal cancer [9,13], liver cancer [14,15], and leukemia [9,16].”
• Long non-coding RNAs and complex diseases: from experimental results to computational models (2016, background): “HOTAIR can also be used as an independent prognostic factor of tumor recurrence for HCC patients after liver transplantation [32, 106].”
• Long noncoding RNAs and the genetics of cancer (2013, background): “In a recent study, Yang et al proposed that high expression levels of HOTAIR could serve as a biomarker to predict tumour recurrence in patients with hepatocellular carcinomas (Yang et al, 2011).”
• Long Non-Coding RNA in the Pathogenesis of Cancers (2019, background): “HOTAIR has been considered to be a risk factor of HCC [112,208].”