IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling

By H. Miki, H. Yamaguchi, S. Suetsugu, T. Takenawa. Nature, 2000

612 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/f1622c84776828dcc02d8db0bf35d6dd49a1c213

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Citations in the corpus

Analysis of the myosinII-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation (2011, background): “Rac1 effectors included IRSp53 (insulin receptor tyrosine kinase substrate p53; ref”
Rac and Rho GTPases in cancer cell motility control (2010, background): “The Arp2/3 complex is activated by Rac through its target insulin receptor tyrosine kinase substrate p53 (IRSp53) [31].”
Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck (2002, background): “For example, IRSp53 has been reported to bind WAVE2 directly and enhance activation of Arp2/3 by recombinant WAVE2 (ref”
Actin cytoskeleton regulation in neuronal morphogenesis and structural plasticity. (2002, background): “Given the key roles of Cdc42 in regulating filopodia (Kozma et al. 1995, Nobes & Hall 1995), in regulating de novo actin polymerization (Rohatgi et al. 1999, Higgs & Pollard 2000), and now in mediating Slit/Robo signaling (Wong et al. 2001), one would expect that loss-of-function mutations of these ”
Rho GTPases and cell migration. (2001, background): “There are three WAVE isoforms (also known as SCARs) so far identified, but WAVE2 seems to be the predominantly expressed isoform in fibroblasts (Miki et al., 2000).”
Local force and geometry sensing regulate cell functions (2006, background): “uk/interpro/DisplayIproEntry?ac=IPR004148">BAR -domain family, BAP2 α/IRSp53 (insulin-receptor substrate protein of 53 kDa) has been shown to be the link between Rac and WAVE (the Wiskott–Aldrich syndrome protein (WASP)-related protein) in regulating membrane rufflin”
Chemotaxis in cancer (2011, background): “Following initial cofilin-dependent protrusion, RAC1 leads to the formation of a WAVE2–insulin receptor substrate p53 (IRSP53; also known as BAIAP2)–ABL-interactor 1 (ABI1) complex, which activates the ARP2–ARP3 comple”
Signal transduction by cell adhesion receptors and the cytoskeleton: functions of integrins, cadherins, selectins, and immunoglobulin-superfamily members. (2002, background): “actin networks (68, 69), and those mediated through mDia1 in forming stress fibers (70).”
Regulation of actin assembly associated with protrusion and adhesion in cell migration. (2008, background): “An alternative model for WAVE2 activation proposed that the protein IRSp53 binds Rac1 and WAVE2 to form a Rac1/ IRSp53/WAVE2 complex that induces membrane ruffling (144)(Fig.”
The role of the Rho GTPases in neuronal development. (2005, background): “Another molecule, the insulin receptor substrate of 53 kDa (IRSp53), has been shown to bind both Rac and Cdc42, and links these Rho GTPases to WAVE2 and Mena (mammalian Ena), respectively (Miki et al. 2000; Krugmann et al. 2001; Miki and Takenawa 2002).”